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Prognostic Impact of Age and Hemoglobin in Acute ST-Segment Elevation Myocardial Infarction Treated With Reperfusion Therapy

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dc.contributor.author Velásquez Rodríguez, Jesús
dc.contributor.author Díez Delhoyo, Felipe
dc.contributor.author Valero Masa, María Jesús
dc.contributor.author Vicent, Lourdes
dc.contributor.author Devesa Cordero, Carolina
dc.contributor.author Sousa Casasnovas, Iago
dc.contributor.author Juárez Fernández, Miriam
dc.contributor.author Angulo Llanos, Rocío
dc.contributor.author Fernández-Avilés, Francisco
dc.contributor.author Martínez Sellés Oliveria Soares, Manuel
dc.date.accessioned 2017-12-16T09:56:48Z
dc.date.available 2017-12-16T09:56:48Z
dc.date.issued 2017
dc.identifier.citation Velásquez-Rodríguez, J., Diez-Delhoyo, F., Valero-Masa, M. J., Vicent, L., Devesa, C., Sousa-Casasnovas, I., ... & Martínez-Sellés, M. (2017). Prognostic Impact of Age and Hemoglobin in Acute ST-Segment Elevation Myocardial Infarction Treated With Reperfusion Therapy. The American Journal of Cardiology, 119(12), 1909-1916. DOI:10.1016/j.amjcard.2017.03.018 spa
dc.identifier.issn 0002-9149
dc.identifier.uri http://hdl.handle.net/11268/6886
dc.description.abstract Advanced age and low hemoglobin levels have been associated with a poor prognosis in ST-segment elevation myocardial infarction (STEMI). We studied 1,111 patients with STEMI who received reperfusion treatment (1,032 [92.9%] primary angioplasty and 79 [7.1%] fibrinolysis without rescue percutaneous coronary intervention). Mean age was 64.1 ± 14.0 years, and 23.2% were women. Patients in the last age quartile (>76 years) were more frequently women, presented more risk factors (except smoking), received thrombolysis less frequently, had less complete revascularization, and presented more complications and higher mortality. Hemoglobin level at admission was associated with age and ranged from 14.8 ± 1.5 g/dl in the first quartile to 13.2 ± 1.8 g/dl in the last, p <0.001. Multivariate analysis identified age as a predictor of in-hospital and long-term mortality (odds ratio 1.04, 95% confidence interval [CI] 1.00 to 1.07, hazard ratio 1.06, 95% CI 1.04 to 1.08). Hemoglobin levels were associated with better survival (odds ratio 0.8, 95% CI 0.6 to 0.9, hazard ratio 0.85, 95% CI 0.78 to 0.92). The other predictors of inhospital mortality were Killip class, chronic kidney disease, left ventricular ejection fraction, significant pericardial effusion, and ventricular arrhythmias. The association of hemoglobin with hospital mortality was seen in men and in women ≥65 years. In men ≥65 years, this association was also present in those with hemoglobin levels in the normal range. In conclusion, in patients with STEMI, hemoglobin is an independent predictor of inhospital and long-term mortality, especially in those aged ≥65 years. This association is also present in men ≥65 years with normal hemoglobin levels. spa
dc.description.sponsorship SIN FINANCIACIÓN spa
dc.language.iso eng spa
dc.title Prognostic Impact of Age and Hemoglobin in Acute ST-Segment Elevation Myocardial Infarction Treated With Reperfusion Therapy spa
dc.type article spa
dc.description.impact 3.171 JCR (2017) Q2, 49/128 Cardiac and Cardiovascular Systems spa
dc.identifier.doi 10.1016/j.amjcard.2017.03.018
dc.rights.accessRights closedAccess spa
dc.subject.uem Infarto de miocardio spa
dc.subject.unesco Enfermedad cardiovascular spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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