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Immune system deregulation in hypertensive patients chronically RAS suppressed developing albuminuria

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dc.contributor.author Martín Lorenzo, Marta
dc.contributor.author González Calero, Laura
dc.contributor.author Baldan Martin, Montserrat
dc.contributor.author López, Juan Antonio
dc.contributor.author Ruiz Hurtado, Gema
dc.contributor.author Cuesta, Fernando de la
dc.contributor.author Segura, Julián
dc.contributor.author Vázquez, Jesús
dc.contributor.author Vivanco, Fernando
dc.contributor.author Barderas, María G.
dc.contributor.author Ruilope Urioste, Luis Miguel
dc.contributor.author Álvarez Llamas, Gloria
dc.date.accessioned 2018-01-08T11:54:47Z
dc.date.available 2018-01-08T11:54:47Z
dc.date.issued 2017
dc.identifier.citation Martin-Lorenzo, M., Gonzalez-Calero, L., Martinez, P. J., Baldan-Martin, M., Lopez, J. A., Ruiz-Hurtado, G., ... & Barderas, M. G. (2017). Immune system deregulation in hypertensive patients chronically RAS suppressed developing albuminuria. Scientific Reports, 7(1), 8894. DOI: 10.1038/s41598-017-09042-2 spa
dc.identifier.issn 2045-2322
dc.identifier.uri http://hdl.handle.net/11268/6991
dc.description.abstract Albuminuria development in hypertensive patients is an indicator of higher cardiovascular (CV) risk and renal damage. Chronic renin-angiotensin system (RAS) suppression facilitates blood pressure control but it does not prevent from albuminuria development. We pursued the identification of protein indicators in urine behind albuminuria development in hypertensive patients under RAS suppression. Urine was collected from 100 patients classified in three groups according to albuminuria development: (a) patients with persistent normoalbuminuria; (b) patients developing de novo albuminuria; (c) patients with maintained albuminuria. Quantitative analysis was performed in a first discovery cohort by isobaric labeling methodology. Alterations of proteins of interest were confirmed by target mass spectrometry analysis in an independent cohort. A total of 2416 proteins and 1223 functional categories (coordinated protein responses) were identified. Immune response, adhesion of immune and blood cells, and phagocytosis were found significantly altered in patients with albuminuria compared to normoalbuminuric individuals. The complement system C3 increases, while Annexin A1, CD44, S100A8 and S100A9 proteins showed significant diminishment in their urinary levels when albuminuria is present. This study reveals specific links between immune response and controlled hypertension in patients who develop albuminuria, pointing to potential protein targets for novel and future therapeutic interventions. spa
dc.description.sponsorship SIN FINANCIACIÓN spa
dc.language.iso eng spa
dc.title Immune system deregulation in hypertensive patients chronically RAS suppressed developing albuminuria spa
dc.type article spa
dc.description.impact 4.122 JCR (2017) Q1, 12/64 Multidisciplinary Sciences spa
dc.identifier.doi 10.1038/s41598-017-09042-2
dc.rights.accessRights openAccess spa
dc.subject.uem Hipertensión spa
dc.subject.uem Inmunología spa
dc.subject.unesco Inmunología spa
dc.subject.unesco Sistema cardiovascular spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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