Mitochondriogenesis genes and extreme longevity

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dc.contributor.author Santiago Dorrego, Catalina spa
dc.contributor.author Garatachea, Nuria spa
dc.contributor.author Yvert, Thomas Paul spa
dc.contributor.author Rodríguez Romo, Gabriel spa
dc.contributor.author Santos-Lozano, Alejandro spa
dc.contributor.author Fiuza Luces, María del Carmen spa
dc.contributor.author Lucía Mulas, Alejandro spa
dc.date.accessioned 2013-11-27T17:26:25Z
dc.date.available 2013-11-27T17:26:25Z
dc.date.issued 2013 spa
dc.identifier.citation Santiago-Dorrego, C., Garatachea, N., Yvert, T., Rodríguez-Romo, G., Santos-Lozano, A., Fiuza-Luces, M. C., & Lucía-Mulas, A. (2013). Mitochondriogenesis genes and extreme longevity. Rejuvenation Research, 16(1), 67-73. spa
dc.identifier.uri http://hdl.handle.net/11268/702
dc.description.abstract Genes of the proliferator-activated receptor delta (PPARD)-peroxisome proliferator-activated receptor γ coactivator 1α (PPARGC1A, also termed PGC1-α)-nuclear respiratory factor (NRF)-mitochondrial transcription Factor A (TFAM) mitochondriogenesis pathway can influence health/disease phenotypes, yet their association with extreme longevity is not known. We studied the association of five common polymorphisms in genes of this pathway (rs2267668, rs8192678, rs6949152, rs12594956, rs1937) and extreme longevity using a case (107 centenarians)-control (284 young adults) design. We found no between-group differences in allele/genotype frequencies, except for CC genotype in rs1937 (p=0.003), with no representation in controls (0%), versus 2.8% in centenarians (2 men, 1 woman). In summary, the studied genetic variants of the PPARD-PPARGC1A-NRF-TFAM pathway were not associated with extreme longevity, yet a marginal association could exist for rs1937. spa
dc.language.iso eng spa
dc.title Mitochondriogenesis genes and extreme longevity spa
dc.type article spa
dc.description.impact 3.931 JCR (2013) Q1, 7/49 Geriatrics & gerontology spa
dc.identifier.doi 10.1089/rej.2012.1382 spa
dc.rights.accessRights openAccess en
dc.subject.unesco Genética humana spa
dc.subject.unesco Vejez spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa

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