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Are respiratory complications of Plasmodium vivax malaria an underestimated problem?

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dc.contributor.author Val, Fernando
dc.contributor.author Avalos, Sara
dc.contributor.author Gomes, André Alexandre
dc.contributor.author Albornoz Zerpa, José Evelio
dc.contributor.author Fontecha, Gustavo
dc.contributor.author Machado Siqueira, André
dc.contributor.author Bassat, Quique
dc.contributor.author Costa Alecrim, Maria Graças
dc.contributor.author Monteiro, Wuelton Marcelo
dc.contributor.author Guimarães Lacerda, Marcus Vinícius
dc.date.accessioned 2018-02-06T13:12:42Z
dc.date.available 2018-02-06T13:12:42Z
dc.date.issued 2017
dc.identifier.citation Val, F., Avalos, S., Gomes, A. A., Zerpa, J. E. A., Fontecha, G., Siqueira, A. M., ... & Lacerda, M. V. G. (2017). Are respiratory complications of Plasmodium vivax malaria an underestimated problem? Malaria Journal, 16(1), 495. DOI: 10.1186/s12936-017-2143-y spa
dc.identifier.issn 1475-2875
dc.identifier.uri http://hdl.handle.net/11268/7060
dc.description.abstract Background: Respiratory complications are uncommon, but often life-threatening features of Plasmodium vivax malaria. This study aimed to estimate the prevalence and lethality associated with such complications among P. vivax malaria patients in a tertiary hospital in the Western Brazilian Amazon, and to identify variables associated with severe respiratory complications, intensive care need and death. Medical records from 2009 to 2016 were reviewed aiming to identify all patients diagnosed with P. vivax malaria and respiratory complications. Prevalence, lethality and risk factors associated with WHO defined respiratory complications, intensive care need and death were assessed. Results: A total of 587 vivax malaria patients were hospitalized during the study period. Thirty (5.1%) developed respiratory complications. Thirteen (43.3%) developed severe respiratory complications, intensive care was required for 12 (40%) patients and 5 (16.6%) died. On admission, anaemia and thrombocytopaenia were common findings, whereas fever was unusual. Patients presented different classes of parasitaemia and six were aparasitaemic on admission. Time to respiratory complications occurred after anti-malarials administration in 18 (60%) patients and progressed very rapidly. Seventeen patients (56.7%) had comorbidities and/or concomitant conditions, which were significantly associated to higher odds of developing severe respiratory complications, need for intensive care and death (p < 0.05). Conclusion: Respiratory complications were shown to be associated with significant mortality in this population. Patients with comorbidities and/or concomitant conditions require special attention to avoid this potential life-threatening complication. Electronic supplementary material: The online version of this article (10.1186/s12936-017-2143-y) contains supplementary material, which is available to authorized users. spa
dc.description.sponsorship SIN FINANCIACIÓN spa
dc.language.iso eng spa
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Internacional *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ *
dc.title Are respiratory complications of Plasmodium vivax malaria an underestimated problem? spa
dc.type article spa
dc.description.impact 2.845 JCR (2017) Q1, 9/37 Parasitology, 3/20 Tropical Medicine; Q2, 38/88 Infectious Diseases spa
dc.identifier.doi 10.1186/s12936-017-2143-y
dc.rights.accessRights openAccess spa
dc.subject.uem Aparato respiratorio -- Enfermedades spa
dc.subject.uem Paludismo spa
dc.subject.uem Cuidados intensivos spa
dc.subject.unesco Aparato respiratorio spa
dc.subject.unesco Malaria spa
dc.subject.unesco Tratamiento médico spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional