Denosumab-related osteonecrosis of the jaw: A literature review

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dc.contributor.author Nifosì, Gianfilippo
dc.contributor.author Nifosì, Antonio Fabrizio
dc.contributor.author Nifosì, Lorenzo
dc.date.accessioned 2018-03-20T11:08:21Z
dc.date.available 2018-03-20T11:08:21Z
dc.date.issued 2017
dc.identifier.citation Nifosì, G., Nifosì, A. F., & Nifosì, L. (2017). Denosumab-related osteonecrosis of the jaw: A literature review. Dental and Medical Problems, 54(4), 423-427. DOI: 10.17219/dmp/76525 spa
dc.identifier.issn 1644-387X
dc.identifier.issn 2300-9020
dc.identifier.uri http://hdl.handle.net/11268/7143
dc.description.abstract Osteonecrosis of the jaw (ONJ) is a rare treatment-related side effect of anti-resorptive drugs whose risk is increased by concomitant local and systemic factors. The number of cases of medication-related ONJ is constantly increasing as a result of the rising tide of molecular-targeted and immunological drugs used in cancer treatment. Denosumab-related ONJ presents peculiar pathophysiological, histopathological, clinical, and therapeutic features compared to that induced by bisphosphonates-related ONJ. This study aimed to compare ONJ induced by denosumab to that caused by bisphosphonates. We have reviewed the literature of the last 5 years on denosumab-related ONJ, focusing on reviews and meta-analyses. The physiopathology of ONJ is unclear. Denosumab acts on receptor activator of nuclear factor kappa-B ligand (RANKL) to inhibit the formation and activity of osteoclasts. The reduction of bone turnover seems to play an important role. Dentists and oral surgeons in the coming years will see an increasing number of patients who are receiving treatment potentially toxic to bone, but also require good dental care. Early recognition of ONJ is essential in the patient’s treatment with denosumab, therefore a close collaboration between the dentist and oncologist is fundamental. spa
dc.description.sponsorship Sin financiación spa
dc.language.iso eng spa
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Internacional *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ *
dc.title Denosumab-related osteonecrosis of the jaw: A literature review spa
dc.title.alternative Martwica kości szczęk wywołana denozumabem – przegląd piśmiennictwa spa
dc.type article spa
dc.description.impact 0.132 SJR (2017) Q4, 114/140 Dentistry (Miscellaneous), 2348/2863 Medicine (Miscellaneous) spa
dc.identifier.doi 10.17219/dmp/76525
dc.rights.accessRights openAccess spa
dc.subject.uem Huesos spa
dc.subject.uem Enfermedades spa
dc.subject.uem Maxilares spa
dc.subject.unesco Enfermedad spa
dc.subject.unesco Odontología spa
dc.description.filiation UEV spa
dc.peerreviewed Si spa

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional