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Cytomegalovirus DNA Detection by Polymerase Chain Reaction in Cerebrospinal Fluid of Infants With Congenital Infection: Associations With Clinical Evaluation at Birth and Implications for Follow-up

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dc.contributor.author Goycochea Valdivia, Walter Alfredo
dc.contributor.author Baquero Artigao, Fernando
dc.contributor.author Rosal, Teresa del
dc.contributor.author Frick, Marie Antoinette
dc.contributor.author Rojo, Pablo
dc.contributor.author Echeverría, María Juncal
dc.contributor.author Noguera Julián, Antoni
dc.contributor.author Bringué, Xavier
dc.contributor.author Saavedra Lozano, Jesús
dc.contributor.author Vives Oñós, Isabel
dc.contributor.author Moliner, Elisenda
dc.contributor.author Cilleruelo Ortega, María José
dc.contributor.author Cuadrado, Irene
dc.contributor.author Colino, Elena
dc.contributor.author Castells, Laura
dc.contributor.author Tagarro García, Alfredo
dc.contributor.author Vilas, Javier
dc.contributor.author Soler Palacin, Pere
dc.contributor.author Blázquez Gamero, Daniel
dc.date.accessioned 2018-04-05T12:05:32Z
dc.date.available 2018-04-05T12:05:32Z
dc.date.issued 2017
dc.identifier.citation Goycochea-Valdivia, W. A., Baquero-Artigao, F., del Rosal, T., Frick, M. A., Rojo, P., Echeverría, M. J., ... & Moliner, E. (2017). Cytomegalovirus DNA Detection by Polymerase Chain Reaction in Cerebrospinal Fluid of Infants With Congenital Infection: Associations With Clinical Evaluation at Birth and Implications for Follow-up. Clinical Infectious Diseases, 64(10), 1335-1342. DOI:10.1093/cid/cix105 spa
dc.identifier.issn 1058-4838
dc.identifier.uri http://hdl.handle.net/11268/7180
dc.description.abstract BACKGROUND: DNA detection of human cytomegalovirus (hCMV) in cerebrospinal fluid (CSF) by polymerase chain reaction (PCR) is a marker of central nervous system (CNS) involvement in congenital hCMV infection (cCMV), but its prognostic value is unknown. METHODS: A multicenter, retrospective study was performed using the Spanish Congenital Cytomegalovirus Infection Database (REDICCMV; http://www.cmvcongenito.es). Newborns with cCMV and a lumbar puncture performed were included and classified according to their hCMV-PCR in CSF result (positive/negative). Clinical characteristics, neuroimaging abnormalities, plasma viral load, and audiological and neurological outcomes of both groups were compared. RESULTS: A total of 136 neonates were included in the study: 21 (15.4%) with positive CSF hCMV-PCR and 115 (84.6%) with negative results. Seventeen patients (81%) in the positive group were symptomatic at birth compared with 52.2% of infants in the negative group (odds ratio [OR], 3.86; 95% confidence interval [CI], 1.28-14.1; P = .01). Only 4 asymptomatic newborns (6.8%) had a positive CSF hCMV-PCR. There were no differences between groups regarding the rate of microcephaly, neuroimaging abnormalities, neurological sequelae at 6 months of age, or plasma viral load. Sensorineural hearing loss (SNHL) at birth was associated with a positive CSF hCMV-PCR result (OR, 3.49; 95% CI, 1.08-11.27; P = .04), although no association was found at 6 months of age. CONCLUSIONS: A positive hCMV-PCR result in CSF is associated with symptomatic cCMV and SNHL at birth. However, no differences in neuroimaging studies, plasma viral load, or outcomes at 6 months were found. These results suggest that hCMV-PCR in CSF may not be a useful prognostic marker in cCMV. spa
dc.description.sponsorship SIN FINANCIACIÓN spa
dc.language.iso eng spa
dc.title Cytomegalovirus DNA Detection by Polymerase Chain Reaction in Cerebrospinal Fluid of Infants With Congenital Infection: Associations With Clinical Evaluation at Birth and Implications for Follow-up spa
dc.type article spa
dc.description.impact 9.117 JCR (2017) Q1, 11/155 Immunology, 3/88 Infectious Diseases, 11/125 Microbiology spa
dc.identifier.doi 1537-6591
dc.identifier.doi 10.1093/cid/cix105
dc.rights.accessRights closedAccess spa
dc.subject.uem ADN spa
dc.subject.uem Líquido cefalorraquídeo spa
dc.subject.uem Lactantes spa
dc.subject.unesco Gen spa
dc.subject.unesco Primera infancia spa
dc.subject.unesco Enfermedad del sistema nervioso spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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