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Health Benefits of an Innovative Exercise Program for Mitochondrial Disorders

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dc.contributor.author Fiuza Luces, María del Carmen
dc.contributor.author Díez Bermejo, Jorge
dc.contributor.author Fernández de la Torre, Miguel
dc.contributor.author Rodríguez Romo, Gabriel
dc.contributor.author Sanz Ayan, Paz
dc.contributor.author Delmiro, Aitor
dc.contributor.author Munguía-Izquierdo, Diego
dc.contributor.author Rodríguez Gómez, Irene
dc.contributor.author Lucía Mulas, Alejandro
dc.contributor.author Morán, María
dc.date.accessioned 2018-06-19T15:33:08Z
dc.date.available 2018-06-19T15:33:08Z
dc.date.issued 2018
dc.identifier.citation Fiuza-Luces, C., Díez-Bermejo, J., la Torre Fernández-de, M., Rodríguez-Romo, G., Sanz-Ayán, P., Delmiro, A., ... & Arenas, J. (2018). Health Benefits of an Innovative Exercise Program for Mitochondrial Disorders. Medicine and science in sports and exercise, 50(6), 1142–1151. spa
dc.identifier.issn 0195-9131
dc.identifier.uri http://hdl.handle.net/11268/7308
dc.description.abstract Purpose We determined the effects of an innovative 8-wk exercise intervention (aerobic, resistance, and inspiratory muscle training) for patients with mitochondrial disease. Methods Several end points were assessed in 12 patients (19–59 yr, 4 women) at pretraining, posttraining, and after 4-wk detraining: aerobic power, muscle strength/power and maximal inspiratory pressure (main end points), ability to perform activities of daily living, body composition, quality of life, and blood myokines (secondary end points). Results The program was safe, with patients’ adherence being 94% ± 5%. A significant time effect was found for virtually all main end points (P ≤ 0.004), indicating a training improvement. Similar findings (P ≤ 0.003) were found for activities of daily living tests, total/trunk/leg lean mass, total fat mass, femoral fracture risk, and general health perception. No differences were found for blood myokines, except for an acute exertional increase in interleukin 8 at posttraining/detraining (P = 0.002) and in fatty acid binding protein 3 at detraining (P = 0.002). Conclusions An intervention including novel exercises for mitochondrial disease patients (e.g., inspiratory muscle training) produced benefits in numerous indicators of physical capacity and induced a previously unreported shift toward a healthier body composition phenotype. spa
dc.description.sponsorship SIN FINANCIACIÓN spa
dc.language.iso eng spa
dc.subject.other Mitochondrial disorders spa
dc.subject.other Innovative exercise program spa
dc.title Health Benefits of an Innovative Exercise Program for Mitochondrial Disorders spa
dc.type article spa
dc.description.impact 4.478 JCR (2018) Q1, 6/83 Sport Sciences spa
dc.identifier.doi 10.1249/MSS.0000000000001546
dc.rights.accessRights closedAccess spa
dc.subject.uem Ejercicio físico spa
dc.subject.uem Calidad de vida spa
dc.subject.unesco Beneficios complementarios spa
dc.subject.unesco Deporte spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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