A New Condition in McArdle Disease: Poor Bone Health-Benefits of an Active Lifestyle

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dc.contributor.author Rodríguez Gómez, Irene
dc.contributor.author Santalla Hernández, Alfredo
dc.contributor.author Díez Bermejo, Jorge
dc.contributor.author Munguía-Izquierdo, Diego
dc.contributor.author Alegre Durán, Luis María
dc.contributor.author Nogales-Gadea, Gisela
dc.contributor.author Arenas, Joaquín
dc.contributor.author Martín Casanueva, Miguel Ángel
dc.contributor.author Lucía Mulas, Alejandro
dc.contributor.author Ara, Ignacio
dc.date.accessioned 2018-06-20T10:15:37Z
dc.date.available 2018-06-20T10:15:37Z
dc.date.issued 2018
dc.identifier.citation Rodríguez-Gómez, I., Santalla, A., Diez-Bermejo, J., Munguía-Izquierdo, D., Alegre, L. M., Nogales-Gadea, G., ... & Ara, I. (2018). A new condition in McArdle disease: Poor bone health—benefits of an active lifestyle. Medicine & Science in Sports & Exercise, 50(1), 3-10. spa
dc.identifier.issn 0195-9131
dc.identifier.issn 1530-0315
dc.identifier.uri http://hdl.handle.net/11268/7320
dc.description.abstract McArdle disease (muscle glycogen phosphorylase deficiency) is a genetic condition associated with exercise intolerance, but how it affects lean mass (LM) and bone mineral content (BMC) and density (BMD) in patients is unknown. We compared these variables between McArdle patients and age-/sex-matched healthy controls and assessed their potential association with physical activity levels in patients. Methods A case–control, cross-sectional design was used to examine LM, BMC, and BMD by using dual-energy x-ray absorptiometry in 136 young adults of both sexes (36 McArdle patients (33 ± 15 yr) and 103 controls (34 ± 11 yr)). Physical activity was assessed using the International Physical Activity Questionnaire. Results McArdle patients had significantly lower LM values in whole-body and regional sites compared with their corresponding controls, whereas no differences were found (except for the trunk) when physically active patients (n = 23) were compared with controls. All bone-related variables were significantly lower in patients than in controls (average difference of 13% for BMC and 7.6% for BMD). By contrast, no significant differences at the lumbar spine, pelvis, and femur sites were found between physically active patients and controls. Conclusions We report on a previously undescribed condition in McArdle patients, poor bone health, which warrants further attention because it can occur in relatively young adults. An active lifestyle can at least partly alleviate this disorder presumably because of its beneficial effect on LM. spa
dc.description.sponsorship Sin financiación spa
dc.language.iso eng spa
dc.subject.other McArdle disease spa
dc.title A New Condition in McArdle Disease: Poor Bone Health-Benefits of an Active Lifestyle spa
dc.type article spa
dc.description.impact 4.478 JCR (2018) Q1, 6/83 Sport Sciences spa
dc.description.impact 2.071 SJR (2018) Q1, 12/289 Orthopedics and Sports Medicine, 5/209 Physical Therapy, Sports Therapy and Rehabilitation, 8/125 Sports Science spa
dc.description.impact No data IDR 2018 spa
dc.identifier.doi 10.1249/MSS.0000000000001414
dc.rights.accessRights closedAccess spa
dc.subject.uem Músculos - Fisiología spa
dc.subject.unesco Deporte spa
dc.subject.unesco Fisiología humana spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa

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