Local functional connectivity suggests functional immaturity in children with attention‐deficit/hyperactivity disorder

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dc.contributor.author Marcos Vidal, Luis
dc.contributor.author Martínez García, Magdalena
dc.contributor.author Petrus, Clara
dc.contributor.author García García, David
dc.contributor.author Martínez, Kenia
dc.contributor.author Janssen, Joost
dc.contributor.author Vilarroya, Óscar
dc.contributor.author Castellanos, Francisco X.
dc.contributor.author Desco, Manuel
dc.contributor.author Sepulcre, Jorge
dc.contributor.author Carmona, Sussana
dc.date.accessioned 2018-07-25T11:39:58Z
dc.date.available 2018-07-25T11:39:58Z
dc.date.issued 2018
dc.identifier.citation Marcos‐Vidal, L., Martínez‐García, M., Pretus, C., Garcia‐Garcia, D., Martínez, K., Janssen, J., ... & Carmona, S. (2018). Local functional connectivity suggests functional immaturity in children with attention‐deficit/hyperactivity disorder. Human Brain Mapping, 39(6), 2442-2454. DOI:10.1002/hbm.24013 spa
dc.identifier.issn 1065-9471
dc.identifier.issn 1097-0193
dc.identifier.uri http://hdl.handle.net/11268/7346
dc.description.abstract Previous studies have associated Attention‐Deficit/Hyperactivity Disorder (ADHD) with a maturational lag of brain functional networks. Functional connectivity of the human brain changes from primarily local to more distant connectivity patterns during typical development. Under the maturational lag hypothesis, we expect children with ADHD to exhibit increased local connectivity and decreased distant connectivity compared with neurotypically developing (ND) children. We applied a graph‐theory method to compute local and distant connectivity levels and cross‐sectionally compared them in a sample of 120 children with ADHD and 120 age‐matched ND children (age range = 7–17 years). In addition, we measured if potential group differences in local and distant connectivity were stable across the age range considered. Finally, we assessed the clinical relevance of observed group differences by correlating the connectivity levels and ADHD symptoms severity separately for each group. Children with ADHD exhibited more local connectivity than age‐matched ND children in multiple brain regions, mainly overlapping with default mode, fronto‐parietal and ventral attentional functional networks (p < .05‐ threshold free‐cluster enhancement–family‐wise error). We detected an atypical developmental pattern of local connectivity in somatomotor regions, that is, decreases with age in ND children, and increases with age in children with ADHD. Furthermore, local connectivity within somatomotor areas correlated positively with clinical severity of ADHD symptoms, both in ADHD and ND children. Results suggest an immature functional state of multiple brain networks in children with ADHD. Whereas the ADHD diagnosis is associated with the integrity of the system comprising the fronto‐parietal, default mode and ventral attentional networks, the severity of clinical symptoms is related to atypical functional connectivity within somatomotor areas. Additionally, our findings are in line with the view of ADHD as a disorder of deviated maturational trajectories, mainly affecting somatomotor areas, rather than delays that normalize with age. spa
dc.description.sponsorship Sin financiación spa
dc.language.iso eng spa
dc.title Local functional connectivity suggests functional immaturity in children with attention‐deficit/hyperactivity disorder spa
dc.type article spa
dc.description.impact 4554 JCR (2018) Q1, 2/14 Neuroimaging, 18/129 Radiology, Nuclear Medicine & Medical Imaging, 61/267 Neurosciences spa
dc.description.impact 2.447 SJR (2018) Q1, 2/45 Anatomy, 23/378 Neurology (clinical), 12/341 Radiology, Nuclear Medicine and Imaging, 11/165 Neurology spa
dc.description.impact No data IDR 2018 spa
dc.identifier.doi 10.1002/hbm.24013
dc.rights.accessRights openAccess spa
dc.subject.uem Trastornos por déficit de atención con hiperactividad spa
dc.subject.uem Niños con trastornos por déficit de atención spa
dc.subject.unesco Niños spa
dc.subject.unesco Enfermedad mental spa
dc.description.filiation UEM spa
dc.relation.publisherversion http://dx.doi.org/10.1002/hbm.24013 spa
dc.peerreviewed Si spa

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