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Significant mitral regurgitation worsens the prognosis and favors the decision of conservative treatment in octogenarians with severe symptomatic aortic stenosis

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dc.contributor.author Gómez Doblas, J. J.
dc.contributor.author López-Garrido, Miguel Antonio
dc.contributor.author Becerra-Muñoz, Víctor Manuel
dc.contributor.author Orellana Figueroa, Hugo Nelson
dc.contributor.author Carro Hevia, Amelia
dc.contributor.author García de la Villa, Bernardo
dc.contributor.author Cornide, L.
dc.contributor.author Martínez Sellés Oliveria Soares, Manuel
dc.date.accessioned 2018-08-13T12:24:47Z
dc.date.available 2018-08-13T12:24:47Z
dc.date.issued 2018
dc.identifier.citation Gómez-Doblas, J. J., López-Garrido, M. A., Becerra-Muñoz, V. M., Orellana-Figueroa, H. N., Hevia, A. C., de la Villa, B. G., ... & Martínez-Sellés, M. (2018). Significant mitral regurgitation worsens the prognosis and favors the decision of conservative treatment in octogenarians with severe symptomatic aortic stenosis. European Journal of Internal Medicine, 55, 40-46. https://doi.org/10.1016/j.ejim.2018.05.018 spa
dc.identifier.issn 0953-6205
dc.identifier.uri http://hdl.handle.net/11268/7372
dc.description.abstract Introduction: The coexistence of significant mitral regurgitation (MR) and severe aortic stenosis is prevalent, has a prognostic impact and makes treatment in the elderly population a complex issue. The aim of this study is to determine the prevalence of significant MR among a population of octogenarians and its influence on treatment and prognosis. Methods: We used the data from PEGASO (Pronóstico de la Estenosis Grave Aórtica Sintomática del Octogenario), a prospective registry that consecutively included 928 patients aged ≥80 years with severe symptomatic aortic stenosis. Results: The prevalence of significant MR was 8.5% (79 patients) and independently associated with the decision to treat conservatively (odds ratio = 2.28, 95% confidence interval: 1.31–3.95, p = 0.003). The group of patients with significant MR had higher overall mortality at 12 months follow-up (51.9% vs 25%, p < 0.001), which remained on division into subgroups based on the presence of comorbidities (Charlson<5: 49.2% vs 21.9%, p < 0.001; and Charlson ≥5: 62.5% vs 41.7%, p = 0.07). Within the group of patients in whom conservative treatment was performed, those with significant MR had higher mortality at one year (62.7% vs 35%, p < 0.001). MR was a significant independent predictor of overall mortality at 12-month follow-up (hazard ratio = 1.87, 95% confidence interval: 1.09–3.18, p = 0.022). Conclusions: Significant MR has a high prevalence and worsens the prognosis of octogenarian patients with severe symptomatic aortic stenosis, especially in patients with conservative treatment, independently of the existence of comorbidities. spa
dc.description.sponsorship SIN FINANCIACIÓN spa
dc.language.iso eng spa
dc.title Significant mitral regurgitation worsens the prognosis and favors the decision of conservative treatment in octogenarians with severe symptomatic aortic stenosis spa
dc.type article spa
dc.description.impact 3.282 JCR (2017) Q1, 27/154 Medicine, General & Internal spa
dc.identifier.doi 10.1016/j.ejim.2018.05.018
dc.rights.accessRights closedAccess spa
dc.subject.uem Estenosis aórtica spa
dc.subject.uem Ancianos spa
dc.subject.unesco Enfermedad cardiovascular spa
dc.subject.unesco Anciano spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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