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Pathological bases and clinical impact of intratumor heterogeneity in clear cell renal cell carcinoma

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dc.contributor.author López, José Ignacio
dc.contributor.author Angulo Cuesta, Javier
dc.date.accessioned 2018-08-14T10:22:16Z
dc.date.available 2018-08-14T10:22:16Z
dc.date.issued 2018
dc.identifier.citation López, J. I., & Angulo, J. C. (2018). Pathological bases and clinical impact of intratumor heterogeneity in clear cell renal cell carcinoma. Current Urology Reports, 19(1), 3. DOI: 10.1007/s11934-018-0754-7 spa
dc.identifier.issn 1527-2737
dc.identifier.issn 1534-6285
dc.identifier.uri http://hdl.handle.net/11268/7382
dc.description.abstract Purpose of review: Intratumor heterogeneity is an inherent event in tumor development that is receiving much attention in the last years since it is responsible for most failures of current targeted therapies. The purpose of this review is to offer clinicians an updated insight of the multiple manifestations of a complex event that impacts significantly patient’s life. Recent findings: Clear cell renal cell carcinoma is the most common renal tumor and a paradigmatic example of a heterogeneous neoplasm. Next-generation sequencing has demonstrated that intratumor heterogeneity encompasses genetic, epigenetic, and microenvironmental variability. Currently accepted protocols of tumor sampling seem insufficient in unveiling intratumor heterogeneity with reliability and need to be updated. This variability challenges the precise morphological diagnosis, its molecular characterization, and the selection of optimal personalized therapies in clear cell renal cell carcinoma, a neoplasm traditionally considered chemo- and radio-resistant. Summary: We review the state of the art of the different approaches to intratumor heterogeneity in clear cell renal cell carcinomas, from the simple morphology to the most sophisticated massive sequencing tools. spa
dc.description.sponsorship SIN FINANCIACIÓN spa
dc.language.iso eng spa
dc.title Pathological bases and clinical impact of intratumor heterogeneity in clear cell renal cell carcinoma spa
dc.type article spa
dc.description.impact 1.983 JCR (2017) Q3, 42/76 Urology & Nephrology spa
dc.identifier.doi 10.1007/s11934-018-0754-7
dc.rights.accessRights closedAccess spa
dc.subject.uem Células cancerosas spa
dc.subject.uem Riñones spa
dc.subject.uem Diagnóstico spa
dc.subject.unesco Cáncer spa
dc.subject.unesco Tratamiento médico spa
dc.subject.unesco Medicina preventiva spa
dc.description.filiation UEM spa
dc.relation.publisherversion http://ezproxy.universidadeuropea.es/login?url=http:/ /dx.doi.org/10.1007/s11934-018-0754-7 spa
dc.peerreviewed Si spa


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