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Advanced interatrial block predicts new-onset atrial fibrillation and ischemic stroke in patients with heart failure: The “Bayes' Syndrome-HF” study

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dc.contributor.author Escobar Robledo, Luis Alberto
dc.contributor.author Bayés de Luna, Antoni
dc.contributor.author Lupón, Josep
dc.contributor.author Baranchuk, Adrian
dc.contributor.author Moliner, Pedro
dc.contributor.author Martínez Sellés Oliveria Soares, Manuel
dc.contributor.author Zamora, Elisabet
dc.contributor.author Antonio, Marta de
dc.contributor.author Domingo, Mar
dc.contributor.author Bayés Genís, Antoni
dc.contributor.author Et al.
dc.date.accessioned 2018-08-17T09:25:42Z
dc.date.available 2018-08-17T09:25:42Z
dc.date.issued 2018
dc.identifier.citation Escobar-Robledo, L. A., Bayés-de-Luna, A., Lupón, J., Baranchuk, A., Moliner, P., Martínez-Sellés, M., ... & Núñez, J. (2018). Advanced interatrial block predicts new-onset atrial fibrillation and ischemic stroke in patients with heart failure: The “Bayes' Syndrome-HF” study. International Journal of Cardiology, 271, 174-180. https://doi.org/10.1016/j.ijcard.2018.05.050 spa
dc.identifier.issn 0167-5273
dc.identifier.uri http://hdl.handle.net/11268/7383
dc.description.abstract Advanced interatrial block (IAB) is characterized by a prolonged (≥120 ms) and bimodal P wave in the inferior leads. The association between advanced IAB and atrial fibrillation (AF) is known as “Bayes' Syndrome”, and there is scarce information about it in heart failure (HF). We examined the prevalence of IAB and whether advanced IAB could predict new-onset AF and/or stroke in HF patients. Methods and results: The prospective observational “Bayes' Syndrome-HF” study included consecutive outpatients with chronic HF. The primary endpoints were new-onset AF, ischemic stroke, and the composite of both. A secondary endpoint included all-cause death alone or in combination with the primary endpoint. Comprehensive multivariable Cox regression analyses were performed. Among 1050 consecutive patients, 536 (51.0%) were in sinus rhythm, 464 with a measurable P wave are the focus of this study. Two-hundred and sixty patients (56.0%) had normal atrial conduction, 95 (20.5%) partial IAB, and 109 (23.5%) advanced IAB. During a mean follow-up of 4.5 ± 2.1 years, 235 patients experienced all-cause death, new-onset AF, or stroke. In multivariable comprehensive Cox regression analyses, advanced IAB was associated with new-onset AF (HR 2.71 [1.61–4.56], P < 0.001), ischemic stroke (HR 3.02 [1.07–8.53], P = 0.04), and the composite of both (HR 2.42 [1.41–4.15], P < 0.001). Conclusions: In patients with HF advanced IAB predicts new-onset AF and ischemic stroke. Future studies must assess whether anticoagulant treatment in Bayes' Syndrome leads to better outcomes in HF. spa
dc.description.sponsorship SIN FINANCIACIÓN spa
dc.language.iso eng spa
dc.title Advanced interatrial block predicts new-onset atrial fibrillation and ischemic stroke in patients with heart failure: The “Bayes' Syndrome-HF” study spa
dc.type article spa
dc.description.impact 4.034 JCR (2017) Q2, 41/128 Cardiac & Cardiovascular Systems spa
dc.identifier.doi 10.1016/j.ijcard.2018.05.050
dc.rights.accessRights closedAccess spa
dc.subject.uem Infarto de miocardio spa
dc.subject.uem Fibrilación auricular spa
dc.subject.uem Cardiopatía coronaria spa
dc.subject.unesco Enfermedad cardiovascular spa
dc.subject.unesco Sistema cardiovascular spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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