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Influence of sex and pregnancy on survival in patients admitted with heart failure: Data from a prospective multicenter registry

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dc.contributor.author Martínez Sellés Oliveria Soares, Manuel
dc.contributor.author Díez-Villanueva, Pablo
dc.contributor.author Álvarez-Gracía, J.
dc.contributor.author Ferrero-Gregori, A.
dc.contributor.author Vives-Borrás, M.
dc.contributor.author Worner, F.
dc.contributor.author Bardají, A.
dc.contributor.author Delgado, Juan F.
dc.contributor.author Vázquez, R.
dc.contributor.author Cinca, J.
dc.contributor.author Et al.
dc.date.accessioned 2018-10-23T11:25:02Z
dc.date.available 2018-10-23T11:25:02Z
dc.date.issued 2018
dc.identifier.citation Martínez‐Sellés, M., Díez‐Villanueva, P., Álvarez‐Gracía, J., Ferrero‐Gregori, A., Vives‐Borrás, M., Worner, F., ... & Cinca J. (2018). Influence of sex and pregnancy on survival in patients admitted with heart failure. Data from a prospective multicenter registry. Clinical Cardiology. 41(7):924-930. https://doi.org/10.1002/clc.22979 spa
dc.identifier.issn 0160-9289
dc.identifier.issn 1932-8737
dc.identifier.uri http://hdl.handle.net/11268/7495
dc.description.abstract Background: Female sex is an independent predictor of better survival in patients with heart failure (HF), but the mechanism of this association is unknown. On the other hand, pregnancies have a strong influence on the cardiovascular system. Hypothesis: Sex and previous gestations might have a prognostic impact on 1-year mortality in patients admitted with HF. Methods: We conducted an observational, prospective, consecutive, multicenter registry of 1831 patients (756 females [41.2%]) admitted with HF. Results: Females had a more advanced age (75.2 ±11.4 vs 70.4 ±12.2 years), less ischemic heart disease (167 [25.3%] vs 446 [47.3%]), and higher left ventricular ejection fraction (52.0% ±16.6% vs 41.1% ±17.0%) than did men (all P values <0.001). During 1-year follow-up, 373 (20.4%) patients died (151 females and 222 males). Female sex was an independent predictor for survival (hazard ratio: 0.79, 95% confidence interval: 0.64-0.98, P = 0.03). In 504 women (65.9%), the exact number of previous pregnancies could be determined; 62 women (12.3%) had no previous pregnancies, 288 (57.1%) women had 1 or 2 pregnancies, and 154 women (30.6%) had ≥3 pregnancies. We found an association between the number of previous gestations and better survival (hazard ratio: 0.878, 95% confidence interval: 0.773-0.997, P = 0.045). Conclusions: In patients admitted with HF, female sex and the number of previous pregnancies are independently associated with better 1-year survival. spa
dc.description.sponsorship Instituto de Salud Carlos III, Spanish Ministry of Health spa
dc.description.sponsorship Fondo Europeo de Desarrollo Regional (FEDER) (Red RIC, RD120042/0001) spa
dc.language.iso eng spa
dc.title Influence of sex and pregnancy on survival in patients admitted with heart failure: Data from a prospective multicenter registry spa
dc.type article spa
dc.description.impact 2.733 JCR (2017) Q2, 58/128 Cardiology & Cardiovascular Medicine spa
dc.identifier.doi 10.1002/clc.22979
dc.rights.accessRights closedAccess spa
dc.subject.uem Infarto de miocardio spa
dc.subject.uem Embarazo spa
dc.subject.uem Pronóstico médico spa
dc.subject.unesco Enfermedad cardiovascular spa
dc.subject.unesco Embarazo spa
dc.subject.unesco Previsión spa
dc.description.filiation UEM spa
dc.relation.publisherversion http://ezproxy.universidadeuropea.es/login?url=http:/ /dx.doi.org/10.1002/clc.22979 spa
dc.peerreviewed Si spa


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