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Impact of bendopnea on postoperative outcomes in patients with severe aortic stenosis undergoing aortic valve replacement

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dc.contributor.author Domínguez Rodríguez, Alberto 
dc.contributor.author Thibodeau, Jennifer T.
dc.contributor.author Ayers, Colby R.
dc.contributor.author Jiménez Sosa, Alejandro
dc.contributor.author Montoto, Javier
dc.contributor.author Prada Arrondo, Pablo C.
dc.contributor.author Abreu González, Pedro
dc.contributor.author Drazner, Mark H.
dc.date.accessioned 2018-10-26T11:12:41Z
dc.date.available 2018-10-26T11:12:41Z
dc.date.issued 2018
dc.identifier.citation Dominguez-Rodriguez, A., Thibodeau, J. T., Ayers, C. R., Jimenez-Sosa, A., Garrido, P., Montoto, J., ... & Drazner, M. H. (2018). Impact of bendopnea on postoperative outcomes in patients with severe aortic stenosis undergoing aortic valve replacement. Interactive Cardiovascular and Thoracic Surgery, 6(1), 808–812. https://doi.org/10.1093/icvts/ivy174 spa
dc.identifier.issn 1569-9293
dc.identifier.issn 1569-9285
dc.identifier.issn 10.1093/icvts/ivy174
dc.identifier.uri http://hdl.handle.net/11268/7502
dc.description.abstract Bendopnea is a recently described symptom of advanced heart failure. Its prevalence and prognostic utility in other cardiac conditions are unknown. METHODS: We prospectively enrolled 108 consecutive patients (75 ± 3 years, 68% men) with severe symptomatic aortic stenosis referred for surgical aortic valve replacement (SAVR). Preoperatively, patients were tested for bendopnea, which was considered to be present when dyspnoea occurred within 30 s of bending forward. Univariable and stepwise multivariable analyses tested the association of bendopnea with preoperative echocardiographic parameters and postoperative clinical outcomes. RESULTS: Bendopnea was present in 46 of 108 (42%) patients. The mean time of onset was 10.5 ± 3.4 s. Bendopnea was associated with higher estimated pulmonary artery systolic pressures [51 (11) mmHg vs 40 (11) mmHg), P < 0.0001], smaller aortic valve area [0.66 (0.16) cm2 vs 0.76 (0.13) cm2, P = 0.0006] and longer duration of mechanical ventilation (P = 0.002) and length of stay in the hospital (P = 0.007). Following SAVR, in-hospital mortality in those with bendopnea versus those without bendopnea was 13% vs 3% (P = 0.07). In multivariable analysis, bendopnea was associated with duration of mechanical ventilation (parameter estimate 2.4, P < 0.0001) and length of stay in the hospital (parameter estimate 10.2, P ≤ 0.0001). CONCLUSIONS: Bendopnea was present in a sizeable minority of patients (42%) with severe aortic stenosis referred for SAVR. Bendopnea was associated with higher pulmonary artery systolic pressure and smaller aortic valve area preoperatively and with longer duration of mechanical ventilation and length of hospitalization postoperatively. These data suggest that bendopnea provides prognostic information in patients with severe aortic stenosis undergoing SAVR. spa
dc.description.sponsorship SIN FINANCIACIÓN spa
dc.language.iso eng spa
dc.title Impact of bendopnea on postoperative outcomes in patients with severe aortic stenosis undergoing aortic valve replacement spa
dc.type article spa
dc.description.impact 1.795 JCR (2017) Q3, 82/128 Cardiac & Cardiovascular Systems; Q4, 49/60 Respiratory Systems spa
dc.rights.accessRights openAccess spa
dc.subject.uem Estenosis aórtica spa
dc.subject.uem Insuficiencia cardiaca spa
dc.subject.unesco Enfermedad cardiovascular spa
dc.subject.unesco Cirugía spa
dc.description.filiation UEC spa
dc.relation.publisherversion http://ezproxy.universidadeuropea.es/login?url=http:/ /dx.doi.org/10.1093/icvts/ivy174 spa
dc.peerreviewed Si spa


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