dc.contributor.author |
Sánchez Rodríguez, Carolina
|
|
dc.contributor.author |
Palao Suay, Raquel |
|
dc.contributor.author |
Rodrigáñez Riesco, Laura |
|
dc.contributor.author |
Aguilar de Armas, María Rosa |
|
dc.contributor.author |
Martín Saldaña, Sergio |
|
dc.contributor.author |
San Román, Julio |
|
dc.contributor.author |
Sanz Fernández, Ricardo
|
|
dc.date.accessioned |
2018-10-29T17:15:36Z |
|
dc.date.available |
2018-10-29T17:15:36Z |
|
dc.date.issued |
2018 |
|
dc.identifier.citation |
Sánchez-Rodríguez, C., Palao-Suay, R., Rodrigáñez, L., Aguilar, M., Martín-Saldaña, S., San Román, J., & Sanz-Fernández, R. (2018). α-Tocopheryl Succinate-Based Polymeric Nanoparticles for the Treatment of Head and Neck Squamous Cell Carcinoma. Biomolecules, 8(3), 97. http://dx.doi.org/10.3390/biom8030097 |
spa |
dc.identifier.issn |
2218-273X |
|
dc.identifier.uri |
http://hdl.handle.net/11268/7525 |
|
dc.description.abstract |
The aim of this work is to study, in an in vitro head and neck squamous cell carcinomas
model the anti-angiogenic and anti-migratory properties of self-assembled polymeric nanoparticles
(NPs) with demonstrated selective anticancer activity. The NPs are based on -tocopheryl succinate
( -TOS) encapsulated in the hydrophobic core of the NPs. We analyzed the effect of the newly
synthetized -TOS-loaded NPs in proliferating endothelial cells and hypopharynx carcinoma
squamous cells and measured markers of angiogenesis, apoptosis and reactive oxygen species
(ROS). -TOS-loaded NPs suppressed angiogenesis by inducing accumulation of ROS and inducing
apoptosis of proliferating endothelial cells. These NPs also decrease the number and quality of
capillary-like tubes in an in vitro three-dimensional (3D) experiment, decrease the production of
the pro-angiogenic vascular endothelial growth factor and down-regulate the expression of its
receptor. The anti-migratory efficacy of -TOS is corroborated in hypopharynx carcinoma cells by
decreasing the secretion of matrix metalloproteases 2 and 9 (MMP-2 and MMP-9) and inhibiting
cell migration. These results confirm that -TOS-based NPs not only present anticancer properties,
but also antiangiogenic properties, therefore making them promising candidates for multi-active
combinatorial anticancer therapy. |
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dc.description.sponsorship |
Spanish Ministry of Economy and Competitiveness (MAT2017-84277-R) |
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dc.description.sponsorship |
Universidad Europea de Madrid (2017/UEM21) |
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dc.language.iso |
eng |
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dc.rights |
Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
* |
dc.rights.uri |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
* |
dc.title |
α-Tocopheryl Succinate-Based Polymeric Nanoparticles for the Treatment of Head and Neck Squamous Cell Carcinoma |
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dc.type |
article |
spa |
dc.description.impact |
4.694 JCR (2018) Q1, 58/299 Biochemistry & Molecular Biology |
spa |
dc.description.impact |
2.525 SJR (2018) Q1, 33/462 Biochemistry, 66/421 Molecular Biology |
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dc.description.impact |
No data IDR 2018 |
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dc.identifier.doi |
10.3390/biom8030097 |
|
dc.rights.accessRights |
openAccess |
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dc.subject.uem |
Nanotecnología |
spa |
dc.subject.uem |
Polímeros |
spa |
dc.subject.unesco |
Nanotecnología |
spa |
dc.subject.unesco |
Polímero |
spa |
dc.description.filiation |
UEM |
spa |
dc.peerreviewed |
Si |
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