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α-Tocopheryl Succinate-Based Polymeric Nanoparticles for the Treatment of Head and Neck Squamous Cell Carcinoma

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dc.contributor.author Sánchez Rodríguez, Carolina
dc.contributor.author Palao Suay, Raquel
dc.contributor.author Rodrigáñez Riesco, Laura
dc.contributor.author Aguilar de Armas, María Rosa
dc.contributor.author Martín Saldaña, Sergio
dc.contributor.author San Román, Julio
dc.contributor.author Sanz Fernández, Ricardo
dc.date.accessioned 2018-10-29T17:15:36Z
dc.date.available 2018-10-29T17:15:36Z
dc.date.issued 2018
dc.identifier.citation Sánchez-Rodríguez, C., Palao-Suay, R., Rodrigáñez, L., Aguilar, M., Martín-Saldaña, S., San Román, J., & Sanz-Fernández, R. (2018). α-Tocopheryl Succinate-Based Polymeric Nanoparticles for the Treatment of Head and Neck Squamous Cell Carcinoma. Biomolecules, 8(3), 97. http://dx.doi.org/10.3390/biom8030097 spa
dc.identifier.issn 2218-273X
dc.identifier.uri http://hdl.handle.net/11268/7525
dc.description.abstract The aim of this work is to study, in an in vitro head and neck squamous cell carcinomas model the anti-angiogenic and anti-migratory properties of self-assembled polymeric nanoparticles (NPs) with demonstrated selective anticancer activity. The NPs are based on -tocopheryl succinate ( -TOS) encapsulated in the hydrophobic core of the NPs. We analyzed the effect of the newly synthetized -TOS-loaded NPs in proliferating endothelial cells and hypopharynx carcinoma squamous cells and measured markers of angiogenesis, apoptosis and reactive oxygen species (ROS). -TOS-loaded NPs suppressed angiogenesis by inducing accumulation of ROS and inducing apoptosis of proliferating endothelial cells. These NPs also decrease the number and quality of capillary-like tubes in an in vitro three-dimensional (3D) experiment, decrease the production of the pro-angiogenic vascular endothelial growth factor and down-regulate the expression of its receptor. The anti-migratory efficacy of -TOS is corroborated in hypopharynx carcinoma cells by decreasing the secretion of matrix metalloproteases 2 and 9 (MMP-2 and MMP-9) and inhibiting cell migration. These results confirm that -TOS-based NPs not only present anticancer properties, but also antiangiogenic properties, therefore making them promising candidates for multi-active combinatorial anticancer therapy. spa
dc.description.sponsorship Spanish Ministry of Economy and Competitiveness (MAT2017-84277-R) spa
dc.description.sponsorship Universidad Europea de Madrid (2017/UEM21) spa
dc.language.iso eng spa
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Internacional *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ *
dc.title α-Tocopheryl Succinate-Based Polymeric Nanoparticles for the Treatment of Head and Neck Squamous Cell Carcinoma spa
dc.type article spa
dc.description.impact 2.552 SJR (2017) Q1, 40/440 Biochemistry, 67/406 Molecular Biology spa
dc.identifier.doi 10.3390/biom8030097
dc.rights.accessRights openAccess spa
dc.subject.uem Nanotecnología spa
dc.subject.uem Polímeros spa
dc.subject.unesco Nanotecnología spa
dc.subject.unesco Polímero spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional