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Immunomodulatory effect of Polypodium leucotomos (Anapsos) in child palatine tonsil model

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dc.contributor.author Sánchez Rodríguez, Carolina
dc.contributor.author Peraza Cruces, Keyliz Rossmery
dc.contributor.author Rodrigáñez Riesco, Laura
dc.contributor.author García Vela, José Antonio
dc.contributor.author Sanz Fernández, Ricardo
dc.date.accessioned 2018-10-31T15:48:16Z
dc.date.available 2018-10-31T15:48:16Z
dc.date.issued 2018
dc.identifier.citation Sánchez-Rodríguez, C., Cruces, K. R. P., Riesco, L. R., García-Vela, J. A., & Sanz-Fernández, R. (2018). Immunomodulatory effect of Polypodium leucotomos (Anapsos) in child palatine tonsil model. International Journal of Pediatric Otorhinolaryngology, 107, 56-61. https://doi.org/10.1016/j.ijporl.2018.01.030 spa
dc.identifier.issn 0165-5876
dc.identifier.issn 1872-8464
dc.identifier.uri http://hdl.handle.net/11268/7536
dc.description.abstract Background: Recurrent tonsillitis might reduce the immunological capability of fighting against the infection of tonsil tissue. Polypodium leucotomos (Anapsos) immunomodulating effect has been subject of research in the last years. The aim of this research is to test the in vitro immunomodulating capacity of Anapsos in a child palatine tonsil explants model. Methods: Palatine tonsils explants of children undergoing amigdalectomy were stimulated with mononuclear cells obtained from their own blood by density gradient centrifugation. Some were then treated with Anapsos while others rest untreated. Cytokines were measured by ELISA, immune cells activation was measured by flow cytometry and activation of immunoglobulins was appreciated by indirect immunofluorescence in tonsils tissue. Results: Anapsos activates Natural Killers cells. It increases IL-2 and IFN-γ levels by the activation of Th2 lymphocytes, and IL-10, by the Th1 lymphocytes. Anapsos also increases immunoglobulins IgM, IgD and IgG4 by Blymphocyte activation in tonsils tissue. Conclusion: Anapsos has an immunomodulating effect, both in humoral and cellular responses, which might benefit children suffering of recurrent tonsillitis as it could enhance their immune system. This effect might reduce the number of episodes suffered and therefore the number of children undergoing surgery. spa
dc.description.sponsorship ASAC Pharma spa
dc.description.sponsorship Laboratorios Centrum S. A. Alicante spa
dc.language.iso eng spa
dc.title Immunomodulatory effect of Polypodium leucotomos (Anapsos) in child palatine tonsil model spa
dc.type article spa
dc.description.impact 1.305 JCR (2018) Q3, 27/41 Othorinolaringoloy, 84/124 Pediatrics spa
dc.identifier.doi 10.1016/j.ijporl.2018.01.030
dc.rights.accessRights closedAccess spa
dc.subject.uem Enfermedades spa
dc.subject.uem Pediatria spa
dc.subject.unesco Enfermedad spa
dc.subject.unesco Pediatría spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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