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Effect of α-tocopherol megadoses on hematologic parameters and antioxidant capacity

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dc.contributor.author Clemente Suárez, Vicente Javier
dc.contributor.author Mielgo Ayuso, Juan
dc.contributor.author Quiles Morales, José Luís
dc.contributor.author Varela López, Alfonso
dc.contributor.author Aranda Ramírez, Pilar
dc.date.accessioned 2018-11-27T18:08:01Z
dc.date.available 2018-11-27T18:08:01Z
dc.date.issued 2017
dc.identifier.citation Clemente-Suárez, V. J., Mielgo-Ayuso, J., Quiles, J. L., Varela-Lopez, A., & Aranda, P. (2017). Effect of α-tocopherol megadoses on hematologic parameters and antioxidant capacity of rats in an ultraendurance probe. Physiology international, 104(4), 291-300. https://dx.doi.org/10.1556/2060.104.2017.4.2 spa
dc.identifier.issn 2498-602X
dc.identifier.uri http://hdl.handle.net/11268/7628
dc.description.abstract This study was aimed to analyze the effect of two different megadoses of α-tocopherol (vit E) in the antioxidant activity and red and white blood series of Wistar rats after a 180-min ultraendurance probe. Three groups of 10 rats were analyzed; VEAG: acute administration of a megadoses of 5,000 IU/kg of vit E the day before the probe; VECG: chronic administration of 1,000 IU/kg/day of vit E for 6 days before the probe; CG: placebo administration. VEAG presented white cells, red blood cells, hematocrit, hemoglobin values significantly higher than CG and VECG (p < 0.05). The mean corpuscular hemoglobin and lymphocytes concentrations were significantly higher in the VECG than in the other two groups (p < 0.05). Similarly, VEAG presented a significantly higher vit E blood concentration than VECG and CG (p < 0.05), and VECG than CG (p < 0.05). Finally, we found a significantly positive correlation between trolox equivalent antioxidant capacity (TEAC) and red blood cells concentration (r = 0.374) and a significantly inverse correlation between TEAC and blood lactate concentration (r = −0.365). Our findings suggest that acute vit E megadoses could protect against transitory sport anemia symptoms and increase the white blood cell count in comparison with the chronic dose and control groups after an ultraendurance probe. spa
dc.description.sponsorship 2016/UEM26 spa
dc.language.iso eng spa
dc.title Effect of α-tocopherol megadoses on hematologic parameters and antioxidant capacity spa
dc.type article spa
dc.description.impact 0.558 JCR (2017) Q4, 78/83 Physiology spa
dc.identifier.doi 10.1556/2060.104.2017.4.2
dc.rights.accessRights closedAccess spa
dc.subject.uem Antioxidantes spa
dc.subject.uem Hematología spa
dc.subject.uem Vitamina E spa
dc.subject.unesco Vitamina spa
dc.subject.unesco Investigación spa
dc.subject.unesco Desarrollo fisiológico spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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