mirage

Incremental effect for antisocial personality disorder genetic risk combining 5-HTTLPR and 5-HTTVNTR polymorphisms

ABACUS/Manakin Repository

Show simple item record

dc.contributor.author García, Luis F. spa
dc.contributor.author Aluja, Antón spa
dc.contributor.author Fibla, J. spa
dc.contributor.author Cuevas, L. spa
dc.contributor.author García López, Óscar spa
dc.date.accessioned 2013-11-27T17:26:30Z
dc.date.available 2013-11-27T17:26:30Z
dc.date.issued 2010 spa
dc.identifier.citation García, L. F., Aluja, A., Fibla, J., Cuevas, L., & García-López, O. (2010). Incremental effect for antisocial personality disorder genetic risk combining 5-HTTLPR and 5-HTTVNTR polymorphisms. Psychiatry Research, 177(1-2), 161-166. spa
dc.identifier.uri http://hdl.handle.net/11268/782
dc.description.abstract As the serotonin transporter gene (SLC6A4 or 5-HTT) is a key regulator of central serotonergic activity, several association studies between Antisocial Personality Disorder (APD) and the SLC6A4 polymorphisms have been conducted in the last decade. In the present study, the role of both 5-HTTLPR and 5-HTTVNTR polymorphisms of the SLC6A4 gene in APD is investigated. A sample of 147 male inmates was analyzed. APD was assessed by Aluja's Antisocial Personality Disorder Scale, a measure that correlates 0.73 with the dimensional score of DSM-IV APD and 0.62 with factor II of the Psychopathy Checklist-Revised. Inmates presenting both 5-HTTLPR S/S+S/L and 5-HTTVNTR 12/12 had a higher risk of being classified in the APD group (Odds ratio=3.48). The results also showed that the genotype and haplotype distribution was more dissimilar when extreme groups were compared with odds ratios up to 6.50. Our results supported that, in addition to the widely investigated 5-HTTLPR polymorphism, the 5-HTTVNTR polymorphism might be an interesting candidate for association studies with APD. Results also suggested that previous failures to replicate the association between serotonin transporter gene polymorphisms and APD, or similar phenotypes, could have been due to an under-representation of extremely high APD subjects in the samples analyzed. spa
dc.language.iso eng spa
dc.title Incremental effect for antisocial personality disorder genetic risk combining 5-HTTLPR and 5-HTTVNTR polymorphisms spa
dc.type article spa
dc.description.impact 2.803 JCR (2010) Q2, 44/128 Psychiatry spa
dc.identifier.doi 10.1016/j.psychres.2008.12.018 spa
dc.rights.accessRights openAccess en
dc.subject.unesco Psiquiatría spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record