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A Critical Insight into the Clinical Translation of PD-1/PD-L1 Blockade Therapy in Clear Cell Renal Cell Carcinoma

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dc.contributor.author Nunes-Xavier, Caroline E.
dc.contributor.author Angulo Cuesta, Javier
dc.contributor.author Pulido, R.
dc.contributor.author López, J.I.
dc.date.accessioned 2019-04-05T08:00:14Z
dc.date.available 2019-04-05T08:00:14Z
dc.date.issued 2019
dc.identifier.citation Nunes-Xavier, C. E., Angulo, J. C., Pulido, R., & López, J. I. (2019). A Critical Insight into the Clinical Translation of PD-1/PD-L1 Blockade Therapy in Clear Cell Renal Cell Carcinoma. Current urology reports, 20(1), 1. http://doi.org/10.1007/s11934-019-0866-8 spa
dc.identifier.issn 1527-2737
dc.identifier.issn 1534-6285
dc.identifier.uri http://hdl.handle.net/11268/7858
dc.description.abstract PURPOSE OF REVIEW: Targeting PD-1/PD-L1 immune checkpoints is a new therapeutic tool in patients with locally advanced and metastatic clear cell renal cell carcinoma (CCRCC). The purpose of this review is to offer clinicians an updated translational insight into the current status of a therapeutic alternative that may impact significantly patient's life. RECENT FINDINGS: Immune checkpoint inhibition has recently demonstrated promising results in selected CCRCC patients with respect to tumor progression and survival. The decision to treat these patients with immune checkpoint inhibitors (ICI) relies on the immunohistochemical detection of PD-1/PD-L1 positivity in inflammatory cells in the tumor, which makes the role of the pathologist crucial, but clinical concern upon the reliability to use immunohistochemistry (IHC) to predict therapeutic response is increasing. We review the state of the art of the immune checkpoint inhibition in CCRCC, from the basic science and its fundamentals to the daily application in clinical routine. spa
dc.description.sponsorship SIN FINANCIACIÓN spa
dc.language.iso eng spa
dc.title A Critical Insight into the Clinical Translation of PD-1/PD-L1 Blockade Therapy in Clear Cell Renal Cell Carcinoma spa
dc.type article spa
dc.description.impact 1.983 JCR (2017) Q3, 42/76 Urology & Nephrology spa
dc.identifier.doi 10.1007/s11934-019-0866-8
dc.rights.accessRights closedAccess spa
dc.subject.uem Cáncer spa
dc.subject.uem Riñones spa
dc.subject.unesco Cáncer spa
dc.subject.unesco Sistema cardiovascular spa
dc.description.filiation UEM spa
dc.relation.publisherversion http://ezproxy.universidadeuropea.es/login?url=http:/ /dx.doi.org/10.1007/s11934-019-0866-8 spa
dc.peerreviewed Si spa


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