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Clinical and prognostic implications of delirium in elderly patients with non-ST-segment elevation acute coronary syndromes

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dc.contributor.author Vives Borrás, Miquel
dc.contributor.author Martínez Sellés Oliveria Soares, Manuel
dc.contributor.author Ariza Solé, Albert
dc.contributor.author Vidán, María Teresa
dc.contributor.author Formiga, Francesc
dc.contributor.author Bueno, Héctor
dc.contributor.author Sanchís, Juan
dc.contributor.author Alegre, Oriol
dc.contributor.author Abu-Assi, Emad
dc.contributor.author Sionis, Alessandro
dc.contributor.author Et al.
dc.date.accessioned 2019-06-17T06:36:29Z
dc.date.available 2019-06-17T06:36:29Z
dc.date.issued 2019
dc.identifier.citation Vives-Borrás, M., Martínez-Sellés, M., Ariza-Solé, A., Vidán, M. T., Formiga, F., Bueno, H., ... & Sionis, A. (2019). Clinical and prognostic implications of delirium in elderly patients with non–ST-segment elevation acute coronary syndromes. Journal of Geriatric Cardiology, 16(2), 121-128. https://doi.org/10.11909/j.issn.1671-5411.2019.02.008 spa
dc.identifier.issn 1671-5411
dc.identifier.uri http://hdl.handle.net/11268/8043
dc.description.abstract Background Elderly patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS) may present delirium but its clinical relevance is unknown. This study aimed at determining the clinical associated factors, and prognostic implications of delirium in old-aged patients admitted for NSTE-ACS. Methods LONGEVO-SCA is a prospective multicenter registry including unselected patients with NSTE-ACS aged ≥ 80 years. Clinical variables and a complete geriatric evaluation were assessed during hospitalization. The association between delirium and 6-month mortality was assessed by a Cox regression model weighted for a propensity score including the potential confounding variables. We also analysed its association with 6-month bleeding and cognitive or functional decline. Results Among 527 patients included, thirty-seven (7%) patients presented delirium during the hospitalization. Delirium was more frequent in patients with dementia or depression and in those from nursing homes (27.0% vs. 3.1%, 24.3% vs. 11.6%, and 11.1% vs. 2.2%, respectively; all P < 0.05). Delirium was significantly associated with in-hospital infections (27.0% vs. 5.3%, P < 0.001) and usage of diuretics (70.3% vs. 49.8%, P = 0.02). Patients with delirium had longer hospitalizations [median 8.5 (5.5–14) vs. 6.0 (4.0–10) days, P = 0.02] and higher incidence of 6-month bleeding and mortality (32.3% vs. 10.0% and 24.3% vs. 10.8%, respectively; both P < 0.05) but similar cognitive or functional decline. Delirium was independently associated with 6-month mortality (HR = 1.47, 95% CI: 1.02–2.13, P = 0.04) and 6-month bleeding events (OR = 2.87; 95% CI: 1.98–4.16, P < 0.01). Conclusions In-hospital delirium in elderly patients with NSTE-ACS is associated with some preventable risk factors and it is an independent predictor of 6-month mortality. spa
dc.description.sponsorship Sin financiación spa
dc.language.iso eng spa
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Internacional *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ *
dc.title Clinical and prognostic implications of delirium in elderly patients with non-ST-segment elevation acute coronary syndromes spa
dc.type article spa
dc.description.impact 2.491 JCR (2019) Q2, 66/138 Cardiac & Cardiovascular Systems; Q3, 30/51 Geriatrics & Gerontology spa
dc.description.impact 0.696 SJR (2019) Q2, 130/362 Cardiology and Cardiovascular Medicine, 50/109 Geriatrics and Gerontology spa
dc.description.impact No data IDR 2019 spa
dc.identifier.doi 10.11909/j.issn.1671-5411.2019.02.008
dc.rights.accessRights openAccess spa
dc.subject.uem Cardiopatía coronaria spa
dc.subject.uem Delirio en ancianos spa
dc.subject.uem Hospitalizados spa
dc.subject.unesco Enfermedad cardiovascular spa
dc.subject.unesco Anciano spa
dc.subject.unesco Gerontología spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional