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Dietary magnesium intake and risk of hypertension in a Mexican adult population: A cohort study

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dc.contributor.author Huitrón Bravo, Gabriel Gerardo
dc.contributor.author Denova Gutiérrez, Edgar
dc.contributor.author Garduño García, José de Jesús
dc.contributor.author Talavera Piña, Juan Osvaldo
dc.contributor.author Herreros Ruiz Valdepeñas, Benjamín
dc.contributor.author Salmerón, Jorge
dc.date.accessioned 2019-06-27T14:46:02Z
dc.date.available 2019-06-27T14:46:02Z
dc.date.issued 2015
dc.identifier.citation Huitrón-Bravo, G. G., Denova-Gutiérrez, E., de Jesús Garduño-García, J., Talavera, J. O., Herreros, B., & Salmerón, J. (2015). Dietary magnesium intake and risk of hypertension in a Mexican adult population: A cohort study. BMC Nutrition, 1(6), 1-8. https://doi.org/10.1186/2055-0928-1-6 spa
dc.identifier.issn 2055-0928
dc.identifier.uri http://hdl.handle.net/11268/8065
dc.description.abstract Background: Hypertension is associated with increased risk of heart disease, stroke, kidney failure, premature mortality, and disability. This rising prevalence of hypertension has been linked to insufficient dietary magnesium intake. However, epidemiological evidence supporting this relationship is inconsistent. To investigate whether magnesium intake affects blood pressure, we examined the association between dietary magnesium intake and the incidence of hypertension in apparently healthy Mexican adults participating in the Health Workers Cohort Study. Methods: A total of 1,378 subjects (77.4% women and 22.6% men), participating in the Health Workers Cohort Study, free of hypertension at baseline (systolic blood pressure <140 mmHg or/and diastolic blood pressure <90 mmHg), were prospectively studied. Magnesium intake was evaluated using a semi-quantitative food frequency questionnaire. The longitudinal relationships between dietary magnesium intake and the incidence of hypertension were analyzed with generalized estimation equations. Results: During a median follow-up of 7 years, 16.4% of women and 31.9% of men developed incident hypertension. After adjustment for age and sex, we found a trend of decreasing diastolic blood pressure with rising magnesium intake, by tertiles (the coefficients were −0.75 mmHg [95% confidence interval (CI): −1.77, 0.27], −1.27 mmHg (95% CI: −2.73, −0.02; P for trend = 0.01). This inverse association was attenuated after further adjustment for known risk factors. In the fully adjusted model, magnesium intake was inversely associated, although not significantly, with the risk of developing hypertension; subjects in the highest tertile of magnesium intake had a decreased risk for hypertension (odds ratio 0.83, 95% CI: 0.49–1.39, P for trend = 0.48). Conclusions: These results do not support the hypothesis that magnesium intake reduces the development of hypertension, although a modest inverse association between magnesium consumption and lower blood pressure cannot be ruled out spa
dc.description.sponsorship Sin financiación spa
dc.language.iso eng spa
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Internacional *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ *
dc.title Dietary magnesium intake and risk of hypertension in a Mexican adult population: A cohort study spa
dc.type article spa
dc.description.impact No data (2015) spa
dc.identifier.doi 10.1186/2055-0928-1-6
dc.rights.accessRights openAccess spa
dc.subject.uem Hipertensión spa
dc.subject.uem Magnesio en el organismo spa
dc.subject.uem Enfermedades spa
dc.subject.unesco Enfermedad cardiovascular spa
dc.subject.unesco Dietética spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional