Synthesis and biological activity of new bispyridinium salts of 4,4 '-bispyridyl-5,5 '-perfluoroalkyl-2,2 '-bisoxazoles

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dc.contributor.author Martín Sánchez-Cantalejo, Yolanda spa
dc.contributor.author Sáez Pizarro, Beatriz spa
dc.contributor.author Monterde, M. I. spa
dc.contributor.author Murillo, M. T. spa
dc.contributor.author Fernández Braña, Miguel spa
dc.date.accessioned 2013-11-27T17:26:34Z
dc.date.available 2013-11-27T17:26:34Z
dc.date.issued 2011 spa
dc.identifier.citation Martín, Y., Sáez-Pizarro, B., Monterde, M. I., Murillo, M. T., & Fernández-Braña, M. (2011). Synthesis and biological activity of new bispyridinium salts of 4, 4′-bispyridyl-5, 5′-perfluoroalkyl-2, 2′-bisoxazoles. European Journal of Medicinal Chemistry, 46(11), 5662-5667. spa
dc.identifier.issn 02235234 spa
dc.identifier.uri http://hdl.handle.net/11268/840
dc.description.abstract A series of bispyridinium compounds were synthesized by a short sequence of reactions from symmetric diamides. All compounds were tested for their antiproliferative activity against HT-29, a cell line derived from a human colon adenocarcinoma, and their inhibitory activity against choline kinase (ChoK), a novel anticancer molecular target already in clinical trials. Most of the compounds analyzed showed good antiproliferative activities, in the micromolar range, with the identification of promising lead molecules as a new family of potential inhibitors of ChoK. (C) 2011 Elsevier Masson SAS. All rights reserved. spa
dc.language.iso eng spa
dc.subject.other Bisoxazol spa
dc.subject.other Bispyridinium spa
dc.subject.other Antiproliferative spa
dc.subject.other Choline Kinase spa
dc.subject.other Inhibitory Activity spa
dc.subject.other Choline Kinase Inhibitors spa
dc.subject.other Antiproliferative Activity spa
dc.subject.other Natural-Products spa
dc.subject.other Oxazoles spa
dc.subject.other Pharmacology & Pharmacy spa
dc.title Synthesis and biological activity of new bispyridinium salts of 4,4 '-bispyridyl-5,5 '-perfluoroalkyl-2,2 '-bisoxazoles spa
dc.type article spa
dc.description.impact 3.346 JCR (2011) Q1, 13/59 Chemistry, medical spa
dc.identifier.doi 10.1016/j.ejmech.2011.09.046 spa
dc.rights.accessRights closedAccess en
dc.subject.unesco Cáncer spa
dc.subject.unesco Tratamiento médico spa
dc.peerreviewed Si spa

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