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Systematic review and meta-analysis of vagus nerve stimulation in the treatment of depression: variable results based on study designs

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dc.contributor.author Rodríguez Martín, José Luis spa
dc.contributor.author Martín-Sánchez, E. spa
dc.date.accessioned 2013-11-27T17:26:34Z
dc.date.available 2013-11-27T17:26:34Z
dc.date.issued 2012 spa
dc.identifier.citation Rodríguez-Martín, J. L., & Martín-Sánchez, E. (2012). Systematic review and meta-analysis of vagus nerve stimulation in the treatment of depression: variable results based on study designs. European Psychiatry, 27(3), 147-155. spa
dc.identifier.issn 17783585 spa
dc.identifier.uri http://hdl.handle.net/11268/848
dc.description.abstract PURPOSE: To determine the efficacy of vagus nerve stimulation (VNS) for treatment of depression. METHODS: We conducted a systematic review and meta-analysis of analytical studies. Efficacy was evaluated according to severity of illness and percentage of responders. RESULTS: We identified 687 references. Of these, 14 met the selection criteria and were included in the review. The meta-analysis of efficacy for uncontrolled studies showed a significant reduction in scores at the Hamilton Depression Rating Scale endpoint, and the percentage of responders was 31.8% ([23.2% to 41.8%], P<0.001). However, the randomised control trial which covered a sample of 235 patients with depression, reported no statistically significant differences between the active intervention and placebo groups (OR=1.61 [95%CI 0.72 to 3.62]; P=0.25). To study the cause of this heterogeneity, a meta-regression was performed. The adjusted coefficient of determination (R2(Adj)) was 0.84, which implies that an 84% variation in effect size across the studies was explained by baseline severity of depression (P<0.0001). CONCLUSION: Currently, insufficient data are available to describe VNS as effective in the treatment of depression. In addition, it cannot be ruled out that the positive results observed in the uncontrolled studies might have been mainly due to a placebo effect. spa
dc.language.iso eng spa
dc.subject.other Research Design* spa
dc.subject.other Vagus Nerve Stimulation* spa
dc.subject.other Depressive Disorder/*Therapy spa
dc.subject.other Humans spa
dc.subject.other Randomized Controlled Trials As Topic spa
dc.subject.other Severity of Illness Index spa
dc.subject.other Treatment Outcome spa
dc.title Systematic review and meta-analysis of vagus nerve stimulation in the treatment of depression: variable results based on study designs spa
dc.type article spa
dc.description.impact 3.285 JCR (2012) Q1, 40/135 Psychiatry spa
dc.identifier.doi 10.1016/j.eurpsy.2011.07.006 spa
dc.rights.accessRights closedAccess en
dc.subject.unesco Psiquiatría spa
dc.peerreviewed Si spa


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