Effect of Early Metoprolol During ST-Segment Elevation Myocardial Infarction on Left Ventricular Strain: Feature-Tracking Cardiovascular Magnetic Resonance Substudy From the METOCARD-CNIC Trial

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dc.contributor.author Podlesnikar, Tomaz
dc.contributor.author Pizarro Sánchez, Gonzalo
dc.contributor.author Fernández Jiménez, Rodrigo
dc.contributor.author Montero Cabezas, J. M.
dc.contributor.author Sánchez González, Javier
dc.contributor.author Bucciarelli Ducci, Chiara
dc.contributor.author Ajmone Marsan, Nina
dc.contributor.author Fras, Z.
dc.contributor.author Bax, J. J.
dc.contributor.author Delgado, Victoria
dc.contributor.author Et al.
dc.date.accessioned 2020-03-16T11:46:37Z
dc.date.available 2020-03-16T11:46:37Z
dc.date.issued 2018
dc.identifier.citation Podlesnikar, T., Pizarro, G., Fernández-Jiménez, R., Montero-Cabezas, J. M., Sánchez-González, J., Bucciarelli-Ducci, C., ... & Ibáñez, B. (2019). Effect of early metoprolol during ST-segment elevation myocardial infarction on left ventricular strain: feature-tracking cardiovascular magnetic resonance substudy from the METOCARD-CNIC trial. JACC: Cardiovascular Imaging, 12(7 Part 1), 1188-1198. https://doi.org/10.1016/j.jcmg.2018.07.019 spa
dc.identifier.issn 1936-878X
dc.identifier.issn 1876-7591
dc.identifier.uri http://hdl.handle.net/11268/8778
dc.description.abstract Objectives This study sought to evaluate the effect of early intravenous metoprolol on left ventricular (LV) strain assessed with feature-tracking cardiovascular magnetic resonance (CMR). Background Early intravenous metoprolol before primary percutaneous coronary intervention (PCI) in ST-segment elevation myocardial infarction (STEMI) portends better outcomes in the METOCARD-CNIC (Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction) trial. Methods A total of 197 patients with acute anterior STEMI who were enrolled in the METOCARD-CNIC trial (100 allocated to intravenous metoprolol before primary PCI and 97 control patients) were evaluated. LV global circumferential strain (GCS) and global longitudinal strain (GLS) were measured with feature-tracking CMR at 1 week and 6 months after STEMI and compared between randomization groups. Results Patients who received early intravenous metoprolol had significantly more preserved LV strain compared with the control patients at 1 week after STEMI (GCS −13.9 ± 3.8% vs. −12.6 ± 3.9%, respectively; p = 0.013; GLS −11.9 ± 2.8% vs. −10.9 ± 3.2%, respectively; p = 0.032). In both groups, LV strain significantly improved during follow-up (mean difference between 6-month and 1-week strain for the metoprolol group: GCS −2.9%, 95% confidence interval [CI]: −3.5% to −2.4%; GLS: −2.9%, 95% CI: −3.4% to −2.4%; both p < 0.001; the control group: GCS −3.4%, 95% CI: −3.9% to −2.8%; GLS −3.4%, 95% CI: −3.9% to −3.0%; both p < 0.001). When dividing the overall cohort of patients in quartiles of GCS and GLS, there were significantly fewer patients in the first quartile (i.e., the worst LV systolic function) who received early intravenous metoprolol compared with control patients at 1 week and 6 months (p < 0.05 for GCS and GLS at both time points). Conclusions In patients with anterior STEMI, early administration of intravenous metoprolol before primary PCI was associated with significantly fewer patients with severely depressed LV GCS and GLS, both at 1 week and 6 months. Feature-tracking CMR represents a complementary tool to evaluate the benefits of cardioprotective therapies. (Effect of METOprolol in CARDioproteCtioN During an Acute Myocardial InfarCtion [METOCARD-CNIC]: NCT013117009) spa
dc.description.sponsorship Sin financiación spa
dc.language.iso eng spa
dc.title Effect of Early Metoprolol During ST-Segment Elevation Myocardial Infarction on Left Ventricular Strain: Feature-Tracking Cardiovascular Magnetic Resonance Substudy From the METOCARD-CNIC Trial spa
dc.type article spa
dc.description.impact 10.975 JCR (2018) Q1, 1/129 Radiology, Nuclear Medicine & Medical Imaging, 8/136 Cardiac & Cardiovascular Systems spa
dc.description.impact 5.102 SJR (2018) Q1, 1/341 Radiology, Nuclear Medicine and Imaging, 7/365 Cardiology and Cardiovascular Medicine spa
dc.description.impact No data IDR 2018 spa
dc.identifier.doi 10.1016/j.jcmg.2018.07.019
dc.rights.accessRights closedAccess spa
dc.subject.uem Cardiología spa
dc.subject.uem Resonancia magnética nuclear (Física) spa
dc.subject.uem Infarto de miocardio spa
dc.subject.unesco Enfermedad cardiovascular spa
dc.subject.unesco Tecnología médica spa
dc.subject.unesco Sistema cardiovascular spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa

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