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Favorable responses to acute and chronic exercise in McArdle patients

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dc.contributor.author Maté-Muñoz, José Luis spa
dc.contributor.author Morán, María spa
dc.contributor.author Pérez Ruiz, Margarita spa
dc.contributor.author Chamorro-Viña, Carolina spa
dc.contributor.author Gómez Gallego, Félix spa
dc.contributor.author Santiago Dorrego, Catalina spa
dc.contributor.author Chicharro García, Luis Miguel spa
dc.contributor.author Foster, Carl spa
dc.contributor.author Nogales-Gadea, Gisela spa
dc.contributor.author Rubio, Juan Carlos spa
dc.date.accessioned 2013-11-27T17:26:36Z
dc.date.available 2013-11-27T17:26:36Z
dc.date.issued 2007 spa
dc.identifier.citation Maté-Muñoz, J. L., Morán, M., Pérez-Ruiz, M., Chamorro-Viña, C., Gómez-Gallego, F., Santiago-Dorrego, C., …, & Rubio, J. C. (2007). Favorable responses to acute and chronic exercise in McArdle patients. Clinical Journal of Sport Medicine, 17(4), 297-303. spa
dc.identifier.uri http://hdl.handle.net/11268/877
dc.description.abstract This study reports acute exercise responses in a large (N = 46) series of patients with McArdle disease and responses to exercise training in a smaller (n = 9) set of patients. Patients were studied during both incremental and steady-state cycle ergometer exercise, using cardiopulmonary testing, and the patients were compared with age- and gender-matched controls. The study was performed in a university setting (clinical exercise physiology laboratory). The 46 patients showed common features of McArdle disease. They were definitively diagnosed by histochemistry, biochemistry, and/or molecular genetic analysis. The 46 controls were healthy, sedentary individuals. Nine patients were studied before and after an 8-month supervised aerobic exercise training program (including five weekly sessions of walking and/or cycling exercise with a duration no greater than 60 minutes). The main indicators of exercise capacity that we measured were peak power output, peak oxygen uptake (VO2peak), and ventilatory threshold (VT). Exercise capacity (peak power output, 35% control; VO2peak, 44% control; VT, 66% control) was markedly depressed in the patients. The patients who trained improved peak power output (25%), VO2peak (44%), and VT (27%), with no evidence of negative outcomes from training. Although not achieving normal values, the response to training put the patients into the lower limit of normal controls. In conclusion, under carefully controlled conditions, patients with McArdle disease may perform acute exercise safely, and they may respond favorably to training. This may offer an additional therapeutic option to help normalize the lifestyles of these patients. spa
dc.language.iso eng spa
dc.title Favorable responses to acute and chronic exercise in McArdle patients spa
dc.type article spa
dc.description.impact 1.636 JCR (2007) Q2, 15/48 Orthopedic, 18/72 Sport sciences; Q3, 45/78 Physiology spa
dc.rights.accessRights openAccess en
dc.subject.unesco Medicina deportiva spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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