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Impregnation of Curcumin into a Biodegradable (Poly-lactic-co-glycolic acid, PLGA) Support, to Transfer Its Well Known In Vitro Effect to an In Vivo Prostate Cancer Model

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dc.contributor.author Gracia, Eulalio
dc.contributor.author Mancini, Andrea
dc.contributor.author Colapietro, Alessandro
dc.contributor.author Mateo, Cristina
dc.contributor.author Gracia, Ignacio
dc.contributor.author Festuccia, Claudio
dc.contributor.author Carmona Delgado, Manuel
dc.date.accessioned 2020-06-19T16:33:18Z
dc.date.available 2020-06-19T16:33:18Z
dc.date.issued 2019
dc.identifier.citation Gracia, E., Mancini, A., Colapietro, A., Mateo, C., Gracia, I., Festuccia, C., & Carmona Delgado, M. (2019). Impregnation of Curcumin into a Biodegradable (Poly-lactic-co-glycolic acid, PLGA) Support, to Transfer Its Well Known In Vitro Effect to an In Vivo Prostate Cancer Model. Nutrients, 11(10), 2312. https://doi.org/10.3390/nu11102312 spa
dc.identifier.issn 2072-6643
dc.identifier.uri http://hdl.handle.net/11268/8976
dc.description.abstract Prostate cancer (PCa) is one of the most common cancers in older men and is associated with high mortality. Despite advances in screening for early detection of PCa, a large proportion of patients continue to be diagnosed with metastatic disease, with ~20% of men showing a high tumor grade and stage. Medicinal plant extracts have a great potential to prevent/treat PCa, as well as to reduce its incidence/prevalence and improve survival rates. One of the most promising extracts is curcumin, which is a major, nontoxic, bioactive compound of Curcuma longa. Curcumin has strong antitumor activity in vitro. However, its potential beneficial in vivo affects are limited by its low intestinal absorption and rapid metabolism. In this study, curcumin was impregnated into a biodegradable poly(lactic-co-glycolic) acid (PLGA) support and characterized by FTIR and DSC, and its release by UV spectrophotometry. PLGA-curcumin was tested in different subcutaneous PCa xenograft models (PC3, 22rv1, and DU145 PCa cell-lines), and its effects evaluated by tumor progression an immuno-histochemical analysis (Trichromic, Ki67 and TUNEL stainings), were compared with those of a commercial curcumin preparation. Our results indicate that curcumin-impregnated PLGA is significantly more active (~2-fold increase) with respect to oral curcumin, which supports its use for subcutaneous administration. spa
dc.description.sponsorship SIN FINANCIACIÓN spa
dc.language.iso eng spa
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Internacional *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ *
dc.title Impregnation of Curcumin into a Biodegradable (Poly-lactic-co-glycolic acid, PLGA) Support, to Transfer Its Well Known In Vitro Effect to an In Vivo Prostate Cancer Model spa
dc.type article spa
dc.description.impact 4.171 JCR (2018) Q1, 16/87 Nutrition & Dietetics spa
dc.identifier.doi 10.3390/nu11102312
dc.rights.accessRights openAccess spa
dc.subject.uem Cáncer spa
dc.subject.uem Medicina preventiva spa
dc.subject.uem Homeopatía spa
dc.subject.unesco Cáncer spa
dc.subject.unesco Medicina preventiva spa
dc.subject.unesco Homeopatía spa
dc.description.filiation UEM spa
dc.peerreviewed Si spa


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional