dc.contributor.author |
Pulido, Federico |
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dc.contributor.author |
Delgado, Rafael |
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dc.contributor.author |
Pérez-Valero, Ignacio |
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dc.contributor.author |
González-García, Juan |
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dc.contributor.author |
Miralles, Pilar |
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dc.contributor.author |
Arranz, Alberto |
spa |
dc.contributor.author |
Hernando Jeréz, María Asunción
|
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dc.contributor.author |
Arribas, José R. |
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dc.date.accessioned |
2013-11-27T17:26:42Z |
|
dc.date.available |
2013-11-27T17:26:42Z |
|
dc.date.issued |
2008 |
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dc.identifier.citation |
Pulido, F., Delgado, R., Pérez-Valero, I., González-García, J., Miralles, P., Arranz, A., ..., & Arribas, J. R. (2008). Long-term (4 years) efficacy of lopinavir/ritonavir monotherapy for maintenance of HIV suppression. Journal of Antimicrobial Chemotherapy, 61(6), 1359-1361. |
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dc.identifier.uri |
http://hdl.handle.net/11268/975 |
|
dc.description.abstract |
Data are scarce on the long-term efficacy of lopinavir/ritonavir monotherapy for the maintenance of HIV suppression. Four years of results of patients randomized to monotherapy in the Only Kaletra (OK) pilot clinical trial are presented. Twenty-one HIV-infected patients with suppressed HIV replication (<50 copies/mL) for at least 6 months and without previous failure while receiving a protease inhibitor-based regimen started lopinavir/ritonavir monotherapy. Follow-up was performed within the OK pilot clinical trial during the first 2 years and according to routine clinical practice during the 3rd and 4th years. Fourteen patients (67%) remain on monotherapy and with RNA <50 copies/mL (intention-to-treat analysis, with missing patients scored as failures). Five patients (24%) had virological rebound and all of them were successfully re-suppressed by adding two nucleosides. No major protease inhibitor mutations were found. Our data support the long-term efficacy and safety of lopinavir/ritonavir monotherapy for the maintenance of HIV suppression, a finding that must be confirmed in larger studies. |
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dc.language.iso |
eng |
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dc.title |
Long-term (4 years) efficacy of lopinavir/ritonavir monotherapy for maintenance of HIV suppression |
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dc.type |
article |
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dc.description.impact |
4.328 JCR (2008) Q1, 8/51 Infectious diseases, 17/91 Microbiology, 31/219 Pharmacology & pharmacy |
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dc.identifier.doi |
10.1093/jac/dkn103 |
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dc.rights.accessRights |
closedAccess |
en |
dc.subject.unesco |
Sida |
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dc.peerreviewed |
Si |
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