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Long-term (4 years) efficacy of lopinavir/ritonavir monotherapy for maintenance of HIV suppression

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dc.contributor.author Pulido, Federico spa
dc.contributor.author Delgado, Rafael spa
dc.contributor.author Pérez-Valero, Ignacio spa
dc.contributor.author González-García, Juan spa
dc.contributor.author Miralles, Pilar spa
dc.contributor.author Arranz, Alberto spa
dc.contributor.author Hernando Jeréz, María Asunción spa
dc.contributor.author Arribas, José R. spa
dc.date.accessioned 2013-11-27T17:26:42Z
dc.date.available 2013-11-27T17:26:42Z
dc.date.issued 2008 spa
dc.identifier.citation Pulido, F., Delgado, R., Pérez-Valero, I., González-García, J., Miralles, P., Arranz, A., ..., & Arribas, J. R. (2008). Long-term (4 years) efficacy of lopinavir/ritonavir monotherapy for maintenance of HIV suppression. Journal of Antimicrobial Chemotherapy, 61(6), 1359-1361. spa
dc.identifier.uri http://hdl.handle.net/11268/975
dc.description.abstract Data are scarce on the long-term efficacy of lopinavir/ritonavir monotherapy for the maintenance of HIV suppression. Four years of results of patients randomized to monotherapy in the Only Kaletra (OK) pilot clinical trial are presented. Twenty-one HIV-infected patients with suppressed HIV replication (<50 copies/mL) for at least 6 months and without previous failure while receiving a protease inhibitor-based regimen started lopinavir/ritonavir monotherapy. Follow-up was performed within the OK pilot clinical trial during the first 2 years and according to routine clinical practice during the 3rd and 4th years. Fourteen patients (67%) remain on monotherapy and with RNA <50 copies/mL (intention-to-treat analysis, with missing patients scored as failures). Five patients (24%) had virological rebound and all of them were successfully re-suppressed by adding two nucleosides. No major protease inhibitor mutations were found. Our data support the long-term efficacy and safety of lopinavir/ritonavir monotherapy for the maintenance of HIV suppression, a finding that must be confirmed in larger studies. spa
dc.language.iso eng spa
dc.title Long-term (4 years) efficacy of lopinavir/ritonavir monotherapy for maintenance of HIV suppression spa
dc.type article spa
dc.description.impact 4.328 JCR (2008) Q1, 8/51 Infectious diseases, 17/91 Microbiology, 31/219 Pharmacology & pharmacy spa
dc.identifier.doi 10.1093/jac/dkn103 spa
dc.rights.accessRights closedAccess en
dc.subject.unesco Sida spa
dc.peerreviewed Si spa


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