Vitamin D and Cardiovascular Health

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dc.contributor.author Guía Galipienso, Fernando de la
dc.contributor.author Martínez Ferrán, María
dc.contributor.author Vallecillo, Néstor
dc.contributor.author Lavie, Carl J.
dc.contributor.author Sanchís-Gomar, Fabián
dc.contributor.author Pareja Galeano, Helios
dc.date.accessioned 2021-02-10T18:04:17Z
dc.date.available 2021-02-10T18:04:17Z
dc.date.issued 2020-20-12
dc.identifier.citation Guía-Galipienso, F., Martínez-Ferrán, M., Vallecillo, N., Lavie, C. J., Sanchís-Gomar, F., & Pareja-Galeano, H. (2020). Vitamin D and cardiovascular health. Clinical Nutrition. Advance online publication. https://doi.org/10.1016/j.clnu.2020.12.025 spa
dc.identifier.issn 0261-5614
dc.identifier.issn 1532-1983
dc.identifier.uri http://hdl.handle.net/11268/9833
dc.description.abstract The principal source of vitamin D in humans is its biosynthesis in the skin through a chemical reaction dependent on sun exposure. In lesser amounts, the vitamin can be obtained from the diet, mostly from fatty fish, fish liver oil and mushrooms. Individuals with vitamin D deficiency, defined as a serum level of 25 hydroxyvitamin D < 20 ng/dl, should be supplemented. Vitamin D deficiency is a prevalent global problem caused mainly by low exposure to sunlight. The main role of 1,25 dihydroxyvitamin D is the maintenance of calcium and phosphorus homeostasis. However, vitamin D receptors are found in most human cells and tissues, indicating many extra-skeletal effects of the vitamin, particularly in the immune and cardiovascular (CV) systems. Vitamin D regulates blood pressure by acting on endothelial cells and smooth muscle cells. Its deficiency has been associated with various CV risk factors and appears to be linked to a higher mortality and incidence of CV disease (CVD). Several mechanisms have been proposed relating vitamin D deficiency to CV risk factors such as renin-angiotensin-aldosterone system activation, abnormal nitric oxide regulation, oxidative stress or altered inflammatory pathways. However, in the latest randomized controlled trials no benefits of vitamin D supplementation for CVD have been confirmed. Although more work is needed to establish the protective role of vitamin D in this setting, according to current evidences vitamin D supplements should not be recommended for CVD prevention. spa
dc.description.sponsorship Sin financiación spa
dc.language.iso eng spa
dc.subject.other Vitamina D spa
dc.subject.other Hipertensión spa
dc.subject.other Enfermedad coronaria spa
dc.title Vitamin D and Cardiovascular Health spa
dc.type article spa
dc.description.impact 6.360 JCR (2019) Q1, 9/89 Nutrition & Dietetics spa
dc.description.impact 1.737 SJR (2019) Q1, 7/91 Critical Care and Intensive Care Medicine spa
dc.description.impact No data IDR 2019 spa
dc.identifier.doi 10.1016/j.clnu.2020.12.025
dc.rights.accessRights openAccess spa
dc.subject.unesco Enfermedad cardiovascular spa
dc.subject.unesco Nutrición spa
dc.subject.unesco Dietética spa
dc.description.filiation UEM spa
dc.relation.publisherversion https://doi.org/10.1016/j.clnu.2020.12.025 spa
dc.peerreviewed Si spa

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