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Impact of frailty and atrial fibrillation in elderly patients with acute coronary syndromes

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dc.contributor.author Esteve Pastor, María Asunción
dc.contributor.author Martín Dorado, Ernesto
dc.contributor.author Alegre, Oriol
dc.contributor.author Formiga, Francesc
dc.contributor.author Sanchís, Juan
dc.contributor.author López Palop, Ramón
dc.contributor.author Martínez Sellés Oliveria Soares, Manuel
dc.contributor.author Vidán, María Teresa
dc.contributor.author Bueno, Héctor
dc.contributor.author LONGEVO‐SCA registry investigators
dc.contributor.author Et al.
dc.date.accessioned 2021-02-11T18:35:46Z
dc.date.available 2021-02-11T18:35:46Z
dc.date.issued 2021
dc.identifier.citation Esteve-Pastor, M. A., Martín, E., Alegre, O., Formiga, F., Sanchís, J., López-Palop, R., Martínez Sellés, M., Vidán, M. T., Bueno, H., Díez-Villanueva, P., Abu Assi, E., Ariza-Solé, A., Marín, F., Castillo Domínguez, J. C., & LONGEVO-SCA registry investigators. (2021). Impact of frailty and atrial fibrillation in elderly patients with acute coronary syndromes. European Journal of Clinical Investigation, e13505. Advance online publication. https://doi.org/10.1111/eci.13505 spa
dc.identifier.issn 0014-2972
dc.identifier.issn 1365-2362
dc.identifier.uri http://hdl.handle.net/11268/9841
dc.description.abstract Background: There is scarce information on the prognostic role of frailty and Atrial Fibrillation (AF) in elderly patients Acute Coronary Syndrome (ACS). Methods: The aim was to analyse the management of elderly patients with frailty and AF who suffered an ACS using data of the prospective multicentre LONGEVO-SCA registry. We evaluated the predictive performance of FRAIL, Charlson scores and AF status for adverse events at 6 months follow-up. Results: A total of 531 unselected patients with ACS and above 80 years old [mean age 84.4 (SD=3.6) years; 322 (60.6%) male] were enrolled, of whom 128 (24.1%) with AF and 145 (27.3%) with frailty. Mutually exclusive number of patients were as follows: non-Frail and sinus rhythm (SR) 304 (57.2%); Frail and SR 99 (18.6%); non-Frail and AF 82 (15.4%); Frail and AF 46 (8.7%). Frail and AF patients compared with non-frail and SR patients had higher risk of all-cause mortality [HR 2.61, (95%CI 1.28-5.31; p=0.008)], readmissions [HR 2.28, (95%CI 1.37-3.80); p=0.002)] and its composite [HR 2.28, (95%CI 1.44-3.60); p<0.001)]. After multivariate adjustment, FRAIL score [HR 1.41, (95%CI 1.02-1.97); p=0.040] and Charlson index [HR 1.32, (95%CI 1.09-1.59); p=0.003] were significantly associated with mortality. AF status was not independently related with adverse events. Conclusions: Frailty but not AF status was independently associated with follow-up adverse events. Frailty status and high Charlson index were independent conditions associated with adverse events during the follow-up. The impact of functional status has a bigger prognostic role over AF status in elderly patients with ACS. spa
dc.description.sponsorship Sin financiación spa
dc.language.iso eng spa
dc.subject.other Insuficiencia cardíaca spa
dc.subject.other Fibrilación atrial spa
dc.subject.other Anciano frágil spa
dc.title Impact of frailty and atrial fibrillation in elderly patients with acute coronary syndromes spa
dc.type article spa
dc.description.impact 3.481 JCR (2019) Q1, 34/165 Medicine, General & Internal spa
dc.description.impact 1.160 SJR (2019) Q1, 21/130 Clinical Biochemistry spa
dc.description.impact No data IDR 2019 spa
dc.identifier.doi 10.1111/eci.13505
dc.rights.accessRights closedAccess spa
dc.subject.unesco Enfermedad cardiovascular spa
dc.subject.unesco Anciano spa
dc.description.filiation UEM spa
dc.relation.publisherversion http://ezproxy.universidadeuropea.es/login?url=http:/ /dx.doi.org/10.1111/eci.13505 spa
dc.peerreviewed Si spa


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