TY - JOUR 
A1 - Tagarro García, Alfredo
AU - Valle Pérez, Rut del
AU - Domínguez Rodríguez, Sara
AU - Baquero Artigao, Fernando
AU - Noguera Julián, Antoni
AU - Vives Oñós, Isabel
AU - Santos, Mar
AU - Hawkins Solís, María Magdalena
AU - Pérez Seoane, Beatriz
AU - Blázquez Gamero, Daniel
AU - Et al.
T1 - Growth Patterns in Children with Congenital Cytomegalovirus Infection
Y1 - 2019
SN - 2048-7193

UR - http://hdl.handle.net/11268/10260
AB - Background: Congenital cytomegalovirus infection (CMVc) affects 0.7%-6% of recent births. Among its clinical manifestations are low weight and length at birth.

Objective: Describe the growth patterns of children with CMVc in their early years.

Methods: Observational, multicenter study of patients with CMVc. Anthropometric data were collected during the first 2 years of life and compared with World Health Organization standards.

Results: Anthropometric characteristics of 383 children with CMVc were studied, of which 198 (51%) were symptomatic at birth. At birth, 9% were small for gestational age (SGA) in terms of their weight and length and 17% had microcephaly. At 24 ± 3 months, 10% had a weight and length ≤2 SD, and 13% a head circumference ≤2 SD. Of those who were SGA at birth, at 24 ± 3 months >20% remained at ≤2 SD of their weight and length. Conversely, 75% of children with low weight or length at 24 ± 3 had not been SGA at birth. 20% of infants with microcephaly at birth remained with microcephaly, and 10% of those without microcephaly developed it at 24 ± 3 months. The average growth rate in length and weight was normal. Patients who were symptomatic at birth, premature and with motor and neurocognitive impairment had a significantly higher risk of low weight and length at 24 ± 3 months.

Conclusion: Around 10% of children with CMVc are at ≤2 SD in weight, length and head circumference at 24 ± 3 months. The lack of adequate growth is associated with symptoms at birth, prematurity and motor and neurocognitive impairment. Growth impairment could be incorporated into the symptomatic spectrum of CMVc.
KW - Citomegalovirus
KW - Insuficiencia de crecimiento
KW - Pediatría
LA - eng
ER -