TY - JOUR 
A1 - Mielgo Rubio, Xabier
AU - Calvo de Juan, Virginia
AU - Luna Tirado, Francisco Javier
AU - Remón, Jordi
AU - Martín Martín, Margarita
AU - Berraondo, Pedro
AU - Jarabo Sarceda, José Ramón
AU - Higuera, Oliver
AU - Conde, Esther
AU - Couñago Lorenzo, Felipe
AU - Et al.
T1 - Immunotherapy Moves to the Early-Stage Setting in Non-Small Cell Lung Cancer: Emerging Evidence and the Role of Biomarkers
Y1 - 2020
SN - 2072-6694
UR - http://hdl.handle.net/11268/10940
AB - Despite numerous advances in targeted therapy and immunotherapy in the last decade, lung cancer continues to present the highest mortality rate of all cancers. Targeted therapy based on specific genomic alterations, together with PD-1 and CTLA-4 axis blocking-based immunotherapy, have significantly improved survival in advanced non-small cell lung cancer (NSCLC) and both therapies are now well-established in this clinical setting. However, it is time for immunotherapy to be applied in patients with early-stage disease, which would be an important qualitative leap in the treatment of lung cancer patients with curative intent. Preliminary data from a multitude of studies are highly promising, but therapeutic decision-making should be guided by an understanding of the molecular features of the tumour and host. In the present review, we discuss the most recently published studies and ongoing clinical trials, controversies, future challenges and the role of biomarkers in the selection of best therapeutic options.
KW - Inmunoterapia
KW - Neoplasias pulmonares
KW - Cáncer
KW - Tratamiento médico
KW - Biología molecular
LA - eng
ER -