TY - JOUR 
A1 - Solano Iturri, Jon Danel
AU - Echevarría, Enrique
AU - Unda, Miguel
AU - Loizaga Iriarte, Ana
AU - Pérez Fernández, Amparo
AU - Angulo Cuesta, Javier
AU - López, José Ignacio
AU - Larrinaga, Gorka
T1 - Clinical Implications of (Pro)renin Receptor (PRR) Expression in Renal Tumours
Y1 - 2021
SN - 2075-4418
UR - http://hdl.handle.net/11268/11522
AB - Background: Renal cancer is one of the most frequent malignancies in Western countries, with an unpredictable clinical outcome, partly due to its high heterogeneity and the scarcity of reliable biomarkers of tumour progression. (Pro)renin receptor (PRR) is a novel receptor of the renin-angiotensin system (RAS) that has been associated with the development and progression of some solid tumours by RAS-dependent and -independent mechanisms. (2) Methods: In this study, we analysed the immunohistochemical expression of PRR at the centre and border in a series of 83 clear-cell renal cell (CCRCCs), 19 papillary (PRCC) and 7 chromophobe (ChRCC) renal cell carcinomas, and the benign tumour renal oncocytoma (RO, n = 11). (3) Results: PRR is expressed in all the tumour subtypes, with higher mean staining intensity in ChRCCs and ROs. A high expression of PRR at the tumour centre and at the infiltrative front of CCRCC tissues is significantly associated with high grade, tumour diameter, local invasion and stage, and with high mortality risk by UCLA integrated staging system (UISS) scale. (4) Conclusions: These findings indicate that PRR is associated with the development and progression of renal tumours. Its potential as a novel biomarker for RCC diagnosis/prognosis and as a promising therapeutic target should be taken into account in the future.
KW - Sistema renina-angiotensina
KW - Carcinoma de Células Renales
KW - Célula
KW - Cáncer
LA - eng
ER -