TY - JOUR 
A1 - González-Baeza, Alicia
AU - Carvajal, Fernando
AU - Bayón, Carmen
AU - Pérez-Valero, Ignacio
AU - Estébanez, Miriam
AU - Bernardino, José Ignacio
AU - Monge, Susana
AU - Lagarde, María
AU - Hernando Jeréz, María Asunción
AU - Arnalich, Francisco
AU - Arribas, José R.
T1 - Pattern of neurocognitive function in patients receiving boosted protease inhibitor monotherapy: a detailed
Y1 - 2014
SN - 13550284
UR - http://hdl.handle.net/11268/3773
AB - In
our study, we included patients virologically suppressed
(≥1 year), on antiretroviral therapy, without concomitant major
neurocognitive confounders, receiving boosted lopinavir
or darunavir as monotherapy (n=96) or as triple therapy with
two nucleoside reverse transcriptase inhibitors (n=95). All
patients underwent a comprehensive neuropsychological test
battery (14 neuropsychological measures, covering seven domains).
Both groups were compared in average score distributions
and rates of neuropsychological deficits. Similar comparisons
were conducted only for patients with neurocognitive
impairment. In the adjusted analysis, we found only small
differences between groups in the entire sample: better verbal
learning (p=0.02; d=0.28) and verbal recall scores (p<0.01;
d=0.25) in patients on boosted protease inhibitor monotherapy
and slightly better motor skills with dominant hand
(p=0.02; d=0.23) scores in patients on triple therapy. No
greater proportion of deficits in the protease inhibitor monotherapy
group was found in any neuropsychological measure.
KW - HIV
KW - Boosted protease inhibitor monotherapy
KW - Neurocognitive impairment
KW - HAND
KW - Neurobiología
KW - SIDA
KW - Sida
LA - eng
ER -