TY - JOUR 
A1 - Díaz Rivas, J. O.
AU - Herrera Carrera, E.
AU - Gallegos Infante, José Alberto
AU - Rocha Guzmán, Nuria E.
AU - González Laredo, Rubén F.
AU - Moreno Jiménez, Martha R.
AU - Ramos Gómez, M.
AU - Reynoso Camacho, R.
AU - Larrosa Pérez, Mar
AU - Gallegos Corona, M. A.
T1 - Gastroprotective potential of Buddleja scordioides Kunth: Effects into the modulation of antioxidant enzymes and inflammation markers in an in vivo model
Y1 - 2015
SN - 03788741
UR - http://hdl.handle.net/11268/3949
AB - Ethnopharmacological relevance: A common plant used to treat several gastric disorders is Buddleja scordioides Kunth,commonly known as salvilla.
Aim of thes tudy: To detect inflammatory markers,in order to evaluate the gastroprotective potential of
salvilla infusions,as this could have beneficial impact on the population exposed to gastric ulcers and
colitis.
Materials and methods: The present work attempted infusions were prepared with B. scordioides (1% w/w) lyophilized and stored.Total phenolic content and GC–MS analysis were performed. Wistar rats were
divided into five groups a negative vehicle control,an indomethacin group,and three
experimental groups,named preventive,curative,and suppressive. All rats were sacrificed under deep
ether anesthesia(6h)after the last oral administration of indomethacin/infusion.The rat stomachs were
promptly excised,weighed,and chilled in ice-cold and 0.9%NaCl.Histological analysis,nitrites
quantification and immunodetection assays were done.
Results: B.scordioides infusions markedly reduced the visible hemorrhagic lesions induced byindomethacin in rat stomachs,also showed down-regulation of COX2, IL-8 and TNFα and up-regulation of
COX-1with a moderate down-regulation of NFkB and lower amount of nitrites.However,this behavior
was dependent on the treatment,showing most down-regulation of COX-2,TNFα and IL-8 in the curative
treatment;more down-regulation of NF-kB in the preventive treatment;and more up-regulation of COX-1 for the suppressor and preventive treatments.
Conclusion: The anti-inflammatory potential of B. scordioides infusions could be related with the
presence of polyphenols as quercetin in the infusion and how this one is consumed.
KW - Buddleja scordioides
KW - Medicinas alternativas
KW - Plantas
KW - Planta medicinal
LA - eng
ER -