TY - JOUR 
A1 - Laurent, François
AU - Brotons-Mas, Jorge
AU - Cid, Elena
AU - López Pigozzi, Diego
AU - Valero, Manuel
AU - Gal Iglesias, Beatriz
AU - Menéndez de la Prida, Liset
T1 - Proximodistal structure of theta coordination in the dorsal hippocampus of epileptic rats
Y1 - 2015
SN - 02706474
UR - http://hdl.handle.net/11268/4427
AB - Coherent neuronal activity in the hippocampal–entorhinal circuit is a critical mechanism for episodic memory function, which is typically impaired in temporal lobe epilepsy. To better understand how this mechanism is implemented and degraded in this condition, we used normal and epileptic rats to examine theta activity accompanying active exploration. Assisted by multisite recordings of local field potentials (LFPs) and layer-specific profiling of input pathways, we provide detailed quantification of the proximodistal coherence of theta activity in the dorsal hippocampus of these animals. Normal rats showed stronger coordination between the temporoammonic and perforant entorhinal inputs (measured from lamina-specific current source density signals) at proximal locations, i.e., closer to CA3; while epileptic rats exhibited stronger interactions at distal locations, i.e., closer to subiculum. This opposing trend in epileptic rats was associated with the reorganization of the temporoammonic and perforant pathways that accompany hippocampal sclerosis, the pathological hallmark of this disease. In addition to this connectivity constraint, we discovered that the appropriate timing between entorhinal inputs arriving over several theta cycles at the proximal and distal ends of the dorsal hippocampus was impaired in epileptic rats.
KW - Coherence
KW - Multisite silicon probes
KW - Proximodistal
KW - Theta oscillations
KW - Neuroanatomía veterinaria
KW - Ratas - Anatomía
KW - Epilepsia
KW - Neurología
KW - Veterinaria
LA - eng
ER -