TY - JOUR 
A1 - Bagán Debón, Leticia María
AU - Jiménez, Yolanda
AU - Leopoldo Rodado, Manuel
AU - Murillo Cortés, Judith
AU - Bagán Sebastián, José Vicente
T1 - Exposed necrotic bone in 183 patients with bisphosphonate-related osteonecrosis of the jaw: Associated clinical characteristics
Y1 - 2017
SN - 16986946
UR - http://hdl.handle.net/11268/6620
AB - The main objective of our study was to identify oral symptoms and signs most likely to be associated
with the exposure of necrotic bone in bisphosphonate-related osteonecrosis of the jaw (BRONJ). The study group consisted of 183 patients with BRONJ. We recorded data on the underlying
disease, bisphosphonate used, location of osteonecrosis, symptoms, pain, fistula development, suppuration,
infection, exposed necrotic bone, and BRONJ stage. The mean age of the patients was 68.22 ± 12.19 years. The sample included 118 (64.5%) women. Breast
cancer and multiple myeloma were the most common underlying diseases, and 50 patients received oral bisphosphonates
for osteoporosis. Dental extractions (69.4%) and mandibular location (74.3%) predominated. The only
two variables influencing the possibility of necrotic bone exposure were intravenous bisphosphonate administration
and the presence of an intraoral fistula (p < 0.05).
 Intravenous bisphosphonate use and intraoral fistula presence were associated with a major predisposition
to bone exposure in patients with BRONJ.
KW - Maxilares
KW - Necrosis
KW - Odontología
LA - spa
ER -