TY - JOUR 
A1 - Sainz de la Cuesta Abbad, Ricardo
AU - González-Cortijo, Lucía
AU - Jiménez de la Peña, Mar
AU - Murillo García, Raquel
AU - Hernández, Ginés
AU - Iacoponi, Sara
AU - Valdés-Devesa, Victoria
AU - Mohedano del Pozo, Rosa Belén
AU - Rubio Alonso, Margarita
T1 - Prognosis and treatment-selection criteria for patients with high-grade stage IIIc-IV serous ovarian, fallopian tube or peritoneal cancer

Y1 - 2019
SN - 15781453

UR - http://hdl.handle.net/11268/8308
AB - Objective: To determine the impact of implementing strict treatment-selection criteria on the overall outcome of women with high-grade serous advanced stage ovarian, fallopian tube, or primary peritoneal carcinoma.
Material and methods: We included patients treated for high-grade serous advanced stage ovarian, fallopian tube, or primary peritoneal carcinoma at our Institution from January 2007 to March 2015. All other non-serous, low-grade histology tumors and secondary
cytoreductions were excluded. strict treatment-selection criteria was used to decide on primary cytoreductive surgery versus neoadjuvant chemotherapy and type of adjuvant therapy. Collected data included patient and tumor characteristics, preoperative diagnostic
procedures, surgical treatment, perioperative complications, and neoadjuvant and adjuvant chemotherapies. Appropriate statistical
tests were used and survival analysis performed.
Results: We identified 71 eligible patients. Mean age was 58.5 ± 11.8 years, 28.2% received neoadjuvant chemotherapy, and 77.5% had
optimal cytoreductive surgery to < 1 cm residual disease. Major complications were observed in 16.9% of women, with no significant
difference between neoadjuvant chemotherapy and primary cytoreductive surgery groups. With a median follow-up of 35.7 months,
median overall survival was not achieved and 57.2% of patients were alive 54 months after surgery. A total of 24 out of 71 (33.8%) died
of disease, 11 (45.8%) within two years after surgery. Median progression-free survival was 19.5 months (95% CI 14.8-24.3).
Conclusions: Applying strict treatment-selection criteria for patients with high-grade serous advanced stage ovarian, fallopian tube,
or primary peritoneal carcinoma ensures few surgical complications and excellent survival rates for the majority of these women.

KW - Aparato genital femenino - Cáncer
KW - Aparato genital femenino - Tumores
KW - Enfermos de cáncer
KW - Cáncer
KW - Mujer
LA - spa
ER -