TY - JOUR 
A1 - Navarro García, José Alberto
AU - Rodríguez Sánchez, Elena
AU - Aceves Ripoll, Jennifer
AU - Abarca Zabalía, Judith
AU - Susmozas Sánchez, Andrea
AU - González Lafuente, Laura
AU - Bada Bosch, Teresa
AU - Hernández, Eduardo
AU - Ruilope Urioste, Luis Miguel
AU - Ruiz Hurtado, Gema
AU - Et al.
T1 - Oxidative Status before and after Renal Replacement Therapy: Differences between Conventional High Flux Hemodialysis and on-Line Hemodiafiltration
Y1 - 2019
SN - 2072-6643
UR - http://hdl.handle.net/11268/8564
AB - Hemodialysis patients experience high oxidative stress because of systemic inflammation and depletion of antioxidants. Little is known about the global oxidative status during dialysis or whether it is linked to the type of dialysis. We investigated the oxidative status before (pre-) and after (post-) one dialysis session in patients subjected to high-flux dialysis (HFD) or on-line hemodiafiltration (OL-HDF). We analyzed carbonyls, oxidized LDL (oxLDL), 8-hydroxy-2′-deoxyguanosine, and xanthine oxidase (XOD) activity as oxidative markers, and total antioxidant capacity (TAC), catalase, and superoxide dismutase activities as measures of antioxidant defense. Indices of oxidative damage (OxyScore) and antioxidant defense (AntioxyScore) were computed and combined into a global DialysisOxyScore. Both dialysis modalities cleared all markers (p < 0.01) except carbonyls, which were unchanged, and oxLDL, which increased post-dialysis (p < 0.01). OxyScore increased post-dialysis (p < 0.001), whereas AntioxyScore decreased (p < 0.001). XOD and catalase activities decreased post-dialysis after OL-HDF (p < 0.01), and catalase activity was higher after OL-HDF than after HFD (p < 0.05). TAC decreased in both dialysis modalities (p < 0.01), but remained higher in OL-HDF than in HFD post-dialysis (p < 0.05), resulting in a lower overall DialysisOxyScore (p < 0.05). Thus, patients on OL-HDF maintain higher levels of antioxidant defense, which might balance the elevated oxidative stress during dialysis, although further longitudinal studies are needed.
KW - Hemodiálisis
KW - Fisiología humana
KW - Sistema cardiovascular
KW - Tratamiento médico
KW - Efectos fisiológicos
LA - eng
ER -