TY - JOUR 
A1 - Rodríguez Sánchez, Elena
AU - Navarro García, José Alberto
AU - Aceves Ripoll, Jennifer
AU - Abarca Zabalía, Judith
AU - Susmozas Sánchez, Andrea
AU - Bada Bosch, Teresa
AU - Hernández Martínez, Eduardo
AU - Mérida Herrero, Evangelina
AU - Ruilope Urioste, Luis Miguel
AU - Ruiz Hurtado, Gema
AU - Et al.
T1 - Variations in Circulating Active MMP-9 Levels during Renal Replacement Therapy
Y1 - 2020
SN - 2218-273X
UR - http://hdl.handle.net/11268/8985
AB - Renal replacement therapy (RRT) is complicated by a chronic state of inflammation and a high mortality risk. However, different RRT modalities can have a selective impact on markers of inflammation and oxidative stress. We evaluated the levels of active matrix metalloproteinase (MMP)-9 in patients undergoing two types of dialysis (high-flux dialysis (HFD) and on-line hemodiafiltration (OL-HDF)) and in kidney transplantation (KT) recipients. Active MMP-9 was measured by zymography and ELISA before (pre-) and after (post-) one dialysis session, and at baseline and follow-up (7 and 14 days, and 1, 3, 6, and 12 months) after KT. Active MMP-9 decreased post-dialysis only in HFD patients, while the levels in OL-HDF patients were already lower before dialysis. Active MMP-9 increased at 7 and 14 days post-KT and was restored to baseline levels three months post-KT, coinciding with an improvement in renal function and plasma creatinine. Active MMP-9 correlated with pulse pressure as an indicator of arterial stiffness both in dialysis patients and KT recipients. In conclusion, active MMP-9 is better controlled in OL-HDF than in HFD and is restored to baseline levels along with stabilization of renal parameters after KT. Active MMP-9 might act as a biomarker of arterial stiffness in RRT.
KW - Diálisis
KW - Tecnología médica
KW - Enfermedad cardiovascular
KW - Tratamiento médico
KW - Tecnología médica
LA - eng
ER -